系统性红斑狼疮患者Th1、Th2细胞因子偏移与类风湿因子和抗心磷脂抗体的相关性研究  

Correlation Between Th1/Th2 Imbalance and Rheumatoid Factors and Anticardiolipin Antibodies in Systemic Lupus Erythematosus

作　　者：吴昌辉[1] 蔡川川[1] 陆善词[1] 梁连辉[1] 蔡昌金[1] 

机构地区：[1]广东省中山市疾病预防控制中心皮肤病防治所,中山528402

出　　处：《中国中西医结合皮肤性病学杂志》2005年第3期141-143,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的评估系统性红斑狼疮(SLE)患者血清中反映Th1/Th2细胞活性的白介素12(IL-12)和白介素13(IL-13)水平的偏移,是否与循环中特异类型的类风湿因子(RF)和抗心磷脂抗体(aCL)相关。方法采用ELISA方法检测31例SLE患者和31例健康志愿者的血清IL-12、IL-13、RF和aCL,采用间接免疫荧光技术和放射免疫扩散法检测自身抗体和免疫球蛋白。结果血清IL-13水平与IgM-RF和IgM-aCL相关,相关系数分别为(0.426;P<0.01)和(0.328;P<0.05),但与IgA-RF,IgG-RF,IgG-aCL和总IgG,IgA和IgM水平无关联。IL-12/IL-13比率小于1组别的IgM-RF和IgM-aCL水平较其他组明显升高。结论SLE患者IgM-RF和IgM-aCL水平的升高与Th2细胞活性占优势成正相关,Th2活性优于Th1活性可能促使SLE患者自身抗体的产生。Objective To evaluate whether the imbalance between IL-12 and IL-13 serum levels, reflecting Thl/Th2 activity is related to class-specific circulating rheumatoid factors （RF） and anticardiolipin （aCL） antibodies in SLE. Methods The levels of serum IL-12, IL-13, RF and aCL antibodies were measured by ELISA in 31 patients with SLE and healthy controls. Serum auto antibodies and immuno-globulin were measured with the method of indirect immunofiuorescence technique and radioimmunodiffusiun. Results The serum level of IL-13 correlated with those of IgM-RF （rs=0.426; P〈0.01） and IgM-aCL （rs=0.328; P〈0.05）, but there were no relationship between IgA-RF, IgG-RF, IgG-aCL and total IgG, IgA and IgM levels. The levels of IgM-RF and lgM-aCL in the group which the ratio of IL-12/IL-13〈1 were significantly higher than those in other two groups. Conclusion The increased levels of both IgM-RF and IgM-aCL in patients with prevalent Th2 activity shows that the predominance of Th2 over Th 1 could drive autoantibody production in SLE patients.

关 键 词：系统性红斑狼疮 TH1/TH2细胞因子 类风湿因子 抗心磷脂抗体 

分 类 号：R593.241[医药卫生—内科学]