血管活性肠肽在银屑病皮损中的表达  

Expression of Vasoactive Intestinal Peptide In Psoriatic Lesions

作　　者：刘春玲[1] 何焱玲[1] 赵红颖[1] 曹梅[1] 陈懿德[1] 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100020

出　　处：《中国中西医结合皮肤性病学杂志》2005年第3期169-170,共2页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的探讨血管活性肠肽(VIP)在银屑病发病中的作用。方法采用免疫组织化学技术检测了VIP在20例银屑病皮损及13例外观正常皮肤的表达,对染色结果进行比较分析。结果银屑病皮损区阳性染色主要分布在棘细胞层和基底层,部分病例角质层和颗粒层也是阳性表达,正常皮肤的阳性表达主要分布在基底层细胞中,银屑病患者VIP表达阳性率和皮损区VIP表达水平明显高于正常皮肤(P<0.05)。结论银屑病皮损区VIP表达增高,提示其在银屑病发病中起一定作用。Objective To study the role of vasoaetive intestinal peptide （VIP） in the pathogenesis of psoriasis. Methods VIP immunoreactivity were studied in 20 psoriatic lesional and normal skin from 13 healthy controls. The immunohistochemistry technique was used to measure the antibodies against VIP. Results Compared with the normal skin, the positive rate and the mean expression level of VIP in lesions of psoriasis were significantly higher than those of healthy controls （P〈0.05）. Conclusion The higher level of VIP in the lesions of patients with psoriasis may take effects on the pathogenesis of psoriasis.

关 键 词：血管活性肠肽 银屑病 免疫组化 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]