人工髓核材料—聚乙烯醇水凝胶的溶胀性能研究  

Swelling Characterization of Poly(vinyl alcohol) Hydrogel for Prosthetic Intervertebral Disc Nucleus

作　　者：李永[1] 高瑾[1] 刘国权[1] 顾正秋[1] 马远征[2] 薛海滨[2] 

机构地区：[1]北京科技大学材料科学与工程学院,北京100083 [2]中国人民解放军309医院骨科,北京100091

出　　处：《生物医学工程学杂志》2005年第5期995-998,共4页Journal of Biomedical Engineering

基　　金：北京市自然科学基金资助项目(2022014);首都医学发展科研基金资助项目(2002-2017)

摘　　要：利用冷冻-解冻法制得聚乙烯醇(PVA)水凝胶弹性体,研究了其用于人工髓核材料的溶胀特性,以及聚乙烯醇浓度、溶胀温度、溶胀体系的pH值对其溶胀性能的影响,采用扫描电镜对其微观形貌进行了观察,并对其溶胀动力学进行了探讨。结果表明,聚乙烯醇水凝胶是一种多孔网状结构,网络孔径大小与水凝胶中聚乙烯醇的含量有关;增加聚乙烯醇的浓度,提高溶胀温度以及溶胀体系的pH值,其平衡溶胀率减小;通过溶胀动力学方程对其溶胀过程进行了描述,水凝胶中聚乙烯醇的含量,试样尺寸以及溶胀体系的pH值,是溶胀速率快慢的重要影响因素。In this study the poly（vinyl alcohol）（PVA） hydrogel elastomer was prepared by freezing-thawing method. The influences of percentage of poly （vinyl alcohol） in hydrogel,pH of solution and swelling temperature upon the swelling characteristic of PVA-hydrogel prosthetic nucleus material were studied. Its micropores were observed using SEM, and the swelling dynamics was further discussed. The experimental results showed that the poly （vinyl alcohol） hydrogel was a kind of network with a lot of micropores, the pore size was related with the PVA content. The maximum swelling ratio decreases when the percentage of PVA in hydrogel, the pH of solution and the swelling temperature were enhanced. The swelling process was described by the equation of swelling dynamics equation. The swelling rate was greatly influenced by the PVA content, the pH of solution and the dimension of hydrogel sample.

关 键 词：人工髓核材料 聚乙烯醇水凝胶 溶胀性能 三维交联网络 生物力学 

分 类 号：R318.08[医药卫生—生物医学工程]