缓释维拉帕米和卡维地洛治疗高血压合并不稳定性心绞痛的疗效观察  

Comparison of therapeutic effects of verapamil SR and carvedilol in hypertension associated with UAP

作　　者：张军汉 翟惠红 傅国琴 张林惠 郭文伟 

机构地区：[1]克拉玛依市人民医院内1科,834000

出　　处：《临床医学》2005年第10期3-5,共3页Clinical Medicine

摘　　要：目的观察缓释维拉帕米和卡维地洛对高血压合并不稳定性心绞痛患者的降压、减少心肌缺血事件及抗室性早搏的效果。方法98例轻、中度高血压合并不稳定性心绞痛患者被随机分成两组,分别服用缓释维拉帕米片(缓释维拉帕米组)和卡维地洛片(卡维地洛组)。比较治疗8周后对心率、坐位血压,24h动态心电图(Holter)中心肌缺血事件及室性早搏的影响。结果服药8周后缓释维拉帕米组和卡维地洛组心率分别下降(8.9±6.1)次/m in和(5.9±4.0)次/m in,坐位血压分别下降(28.0±7.8)/(19.8±7.1)mmHg和(19.5±6.9)/(18.2±5.4)mmHg,24h Holter示缓释维拉帕米组和卡维地洛组缺血事件次数分别减少88.4%和56.5%,缺血时间分别缩短82.7%和41.6%,缺血时间缩短两组间比较P<0.05,抗室性早搏总有效率分别为72.3%和29.4%(P<0.05)。结论缓释维拉帕米和卡维地洛均有较好的降压作用(P>0.05),但缓释维拉帕米减慢心率、减少心肌缺血事件及抗室性早搏的作用优于卡维地洛。Objective To evaluate and compare the anti - hypertension,antiischemia and anti - premature ventricular beats effects of verapamil SR and carvedilol on patients with essential hypertension（EH） associated with unstable angina（UAP）. Methods Ninety - two patients with EH and UAP were randomly divided into verapamil SR treatment group （50 cases） and earvedilol treatment group（48 cases）. The indexes of observation included variety of heart rate, blood pressue,cardiac arrhythmias and myocardial schemia in 24h Hoher gram after 8 weeks treatment in both groups. Results The reduced rest heart rate were（ 8.9± 6. 1 ）beats/min in verapamil SR treatment group, （5, 9± 4.0 ）beats/min in cavedilol trearment group. The reducod blood pressue were（ 28.0 ± 7.8 ）/（ 19.8 ± 7. 1 ） mmHg and （ 19. 5 ± 6. 9 ）/（ 18.2 ± 5. 4 ） mmHg respectively. The beats of myocardial ischemia were reduced 88,4% and 56.5% respectively. The time of myocardial isehemia were reduced 82.7% and 41.6% （ P 〈 0.05 ）. The effective rates were 72, 3% and 29.4% （ P 〈 0.05 ） respevtively for premature ventricular beats. Conclusion Both groups of verapamil SR and carvedlol reduce blood pressue effectively in reducing heart rates,antiischemia and anti - premature ventricular beats, the efficacy of verapamil SR is better than earvedilol.

关 键 词：缓释维拉帕米 卡维地洛 高血压 心肌缺血 不稳定性心绞痛患者 缓释维拉帕米 卡维地洛片 中度高血压 疗效观察 治疗 24H动态心电图 心肌缺血事件 室性早搏 

分 类 号：R541.3[医药卫生—心血管疾病]