人工肝支持系统治疗重症肝炎的临床观察  

Clinical Observation of Patients with Severe Hepatitis Treated by Artificial Livers Support System

作　　者：易峰 叶中景 徐月明 曾志红 

机构地区：[1]湖南省岳阳市一人民医院血液净化中心,湖南岳阳414000

出　　处：《医学临床研究》2005年第10期1404-1406,共3页Journal of Clinical Research

摘　　要：【目的】探讨应用人工肝支持系统治疗重症肝炎的疗效和安全性。【方法】对50例重症肝炎患者应用人工肝方法进行治疗,通过比较治疗前后患者的临床症状,肝功能、电解质、凝血酶原活动度(PTA)、胆碱酯酶(CHE)变化及存活率和不良反应,并与40例病情相似行常规治疗的患者相对照。【结果】人工肝治疗组临床症状明显改善,近期存活率50%,对照组为30.0%。治疗组不良反应10%,血清谷丙转氨酶(ALT)、总胆红素(TBIL)、总胆汁酸(TBA)均较治疗前和对照组明显下降,且有显著差异(P<0.01),PTA、胆固醇(CHOL)、CHE则明显上升(P<0.01)。电解质、血常规两组及治疗前后相比无明显变化。【结论】人工肝支持系统能明显改善重症肝炎患者的临床症状和生化指标,提高存活率,其对重症肝炎是安全有效的。[Objective]To investigate the curative effect and safety of artificial livers support system （ALSS）in patients with severe hepatitis. [Methods]Fifty patients with severe hepatitis were treated by way of artificial livers support system. The clinical symptoms, liver function,electrolytes, prothrombin activity, cholinesterase,survival rate and the side effects were observed. The control group consists of 40 similar patients treated by the conventional therapy. [Resuhs]In 50 patients with severe hepatitis, after the treatment by artificial livers support system, the clinical symptoms were improved. Survival rate in the treatment group was 50 %, 30.0% in the control group. The side effects in the treatment group was 10%. There were obvious decreases in serum ALT, TBIL,TBA and clearly increases in serum CHE,CHOL, PTA after treatment compared with thai before treatment（ P 〈0.01）. but there was no obvious change in electrolytes and blood cell after treatment. [Conclusion]Artificial livers support system can obviously improve the clinical symptoms and the biochemical parameters, increase the survival rate. It is effective and safe in severe hepatitis.

关 键 词：肝炎 病毒性 人/治疗 生命支持疗法 

分 类 号：R512.6[医药卫生—内科学]