凝结芽胞杆菌TBC 169株对肠道致病菌的抑菌作用  

Inhibitory effect of Bacillus coagulans TBC 169 strain on the pathogenic bacteria in intestinal tract

作　　者：崔云龙 闫述翠 万阜昌 

机构地区：[1]青岛东海药业有限公司,山东青岛266400 [2]北京天施康医药科技发展有限公司,北京100037

出　　处：《中国微生态学杂志》2005年第5期333-334,338,共3页Chinese Journal of Microecology

基　　金：国家科技部创新基金项目(01C26211100765);国家科技部863计划项目(2003AA2Z3C50)

摘　　要：目的研究凝结芽胞杆菌TBC 169株对大肠埃希菌、痢疾志贺菌、伤寒沙门菌、普通变形杆菌、铜绿假单胞菌和金黄色葡萄球菌的抑制作用。方法先将大肠埃希菌、痢疾杆菌等6种菌分别进行单独培养,测定不同培养时间内的pH和活菌数,然后将凝结芽胞杆菌TBC 169株分别和致病菌进行混合培养,再测pH和活菌数,并与单独培养时的测定情况进行比较。结果凝结芽胞杆菌TBC 169株对大肠埃希菌、痢疾志贺菌、伤寒沙门菌等6种菌均有明显的抑制作用,尤其是对伤寒沙门菌和铜绿假单胞菌的抑制作用更强。结论凝结芽胞杆菌TBC 169株对肠道致病菌有显著的抑制作用。Objective To study the inhibitory effect of Bacillus coagulans（BC） TBC 169 strain on E. coli, Shigella dysenteriae ,Salmonella typhi ,Proteus vulgaris ,Pseubomonas aeruginosa and Staphylococcus aureus which belong to pathogenic bacteria of intestinal tract. Methods The pathogenic bacteria were singly cultured first,respectively,and pH levels and viable bacteria amounts were determined at various time. Then BC was mixture cultured with other bacteria,respectiely,and pH levels and viable bacteria amounts were detemined again. The data obtained from the single and mixed culture were compared. Results BC TBC 169 strain had obvious inhibitory effect on the E. coli,Shigella dysenteriae,Salmonella typhi etc,peculiar ,on the inhibitor effect of the Salmonella typhi and Pseubomonas aeruginosa was very good. Conclusion BC TBC 169 strain had obvious inhibitory effect on the pathogenic becteriae of intestinal tract.

关 键 词：凝结芽胞杆菌 单独培养 混合培养 抑菌作用 

分 类 号：R722.6[医药卫生—儿科]