滇丹参提取液对心肌缺血大鼠血液流变性的影响  

Effects of S.yunnanensis C.H.Wright on hemodynamics in myocardial ischemia rats

作　　者：何洪静[1] 练生利 李惠兰[3] 张荣平[3] 

机构地区：[1]成都军区昆明总医院,云南昆明650032 [2]重庆市九龙坡区第二人民医院,重庆400052 [3]昆明医学院

出　　处：《西南国防医药》2005年第5期465-467,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：云南省科委应用基础研究基金资助项目(NO.98C067N)

摘　　要：目的:探讨云南产甘西鼠尾属药物滇丹参对大鼠血液流变性的影响。方法:结扎大鼠冠状动脉左前降支造成急性心肌梗塞模型,股静脉给药,1.5h后颈动脉取血测定全血粘度、血浆粘度、红细胞压积、血浆纤维蛋白原含量等血液流变学指标。结果:滇丹参10g/kg4、g/kg2、g/kg三种剂量均能显著降低高、中、低切变率下的全血粘度和血浆粘度(P<0.01,P<0.05),能显著降低纤维蛋白原含量(P<0.01);10g/kg时,能降低红细胞压积(P<0.01,P<0.05)。结论:滇丹参具有改善心肌缺血大鼠血液流变异常的作用。Objective： To compare the effects of S. yunnanensis C. H. Wright and Slavia mitiorrhiza Bunge on hemodynamics in myocardial ischemia rats. Methods： The myocardial ischemia model was established by ligating the left anterior descending coronary artery（LAD） in rats. Both drugs were injected through femoral vein into the models. Then 1.5 h late, the whole blood viscosity, plasma viscosity, hematocrit（HCT） of red blood cell, the contents of plasma fibrinogen were observed. Results： Both drugs could markedly reduce the whole blood and plasma viscosities under high, middle and low shear rates（P〈0. 01-0. 05）. With high and middle dose, the drugs could decrease the contents of plasma fibrinogen（P〈0. 01）. With high dose, both of them could reduce HCT（P〈0.01-0.05）. Conclusion： S. yunnanensis C. H. Wright can significantly improve the hemodynarnics in myocardial ischemia rats.

关 键 词：滇丹参 心肌缺血 血液流变性 

分 类 号：R541[医药卫生—心血管疾病]