平面配对显像对^(99)Tc^m-C_(50),^(67)Ga的内照射辐射吸收剂量分析  

Calculation of irradiated absorbed dosage in ^(99)Tc^m-C_(50),^(67)Ga by paired planar imaging

作　　者：吕中伟[1] 管梁[2] 蔡海东[1] 侯敏[1] 余飞[1] 郭万华[2] 朱承谟[2] 

机构地区：[1]同济大学附属第十人民医院核医学科,上海200072 [2]上海第二医科大学附属瑞金医院核医学科,上海200025

出　　处：《中国医学影像技术》2005年第10期1592-1594,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(39770236);上海市科学技术发展基金(024119102)资助。

摘　　要：目的分析99Tcm-C50和67Ga在病理状态下对各主要器官和全身的内照射剂量。方法应用SPECT进行平面配对显像,以自行设计软件计算99Tcm-C50和67Ga在直肠癌和淋巴瘤病人各组织器官的辐射吸收剂量。结果发现99Tcm-C50主要累积在肝、肾中,肝、肾、肺和心的辐射吸收剂量较高;67Ga主要累积在肠道、肝脏、肾脏和骨骼内,肠、肝、骨骼、肾脏和心脏内辐射吸收剂量较高。结论本研究与ICRP第53号出版物公布的结论相近,且检测及计算方法简单、可靠,为临床合理应用上述两种放射性药物提供了实验性依据。Objective To analyze the radiation dose from internal exposure to individual organs and the whole body under pathological conditions. Methods Following paired planar imaging with SPECT, radiation absorbed doses of ^99Tc^m-C50 and ^67Ga to individual organs or tissues were calculated using self-designed software in patients with rectal cancer or lymphoma. Results ^99Tc^m-C50 was accumulated mainly in liver and kidney. The high radiation absorbed doses were found in the liver, kidney, lung and heart. ^67 Ga was accumulated mainly in the intestines, liver, kidney and skeletons. The high radiation absorbed doses were found in the skeletons, intestines, liver, kidney and heart. Conclusion These results are close to those published in No 53 of ICRP. The measurement and calculation provide a simple and relatively reliable way and experimental evidence for those two radiopharmaceuticals in clinical practice.

关 键 词：平面配对显像 ^99Tc^m-C50 ^67Ga 辐射吸收剂量 

分 类 号：R817.4[医药卫生—影像医学与核医学]