某些抗运动病药物对前庭受刺激时兔脑电功率谱的影响  被引量:4

Effects of some anti-motion sickness drugs on EEG power spectra during vestibular stimulation in rab-bits

在线阅读下载全文

作  者:姜正林[1] 庄坚[1] 

机构地区:[1]南通医学院航海医学研究所

出  处:《中华航海医学杂志》1996年第2期84-87,共4页

摘  要:目的:观察一些抗运动病药物对前庭受刺激时兔脑电功率谱的影响。方法:前庭刺激为持续45分钟的正弦旋转,峰角速度60°/s,正弦周期4秒。结果与结论:旋转刺激引起生理盐水对照组动物大脑皮质抑制。哌醋甲酯可逆转这种作用,支持Kohl提出的该药抗运动病的作用假说。东莨菪碱加深了前庭刺激对大脑皮质的抑制。而山莨菪碱可阻断前庭刺激对大脑皮质的抑制,且文献报道其外周副作用亦小。因此山莨菪碱用于抗运动病比东莨菪碱对机体有利。Aim:To observe the effects of some anti-motion sickness drugs on EEG power spectra during vestibular stimulation in rabbits. Methods:The vestibular stimulation used was a continued 45 min sinusoidal rotation with a peak angular speed of 60°/s and a cycle of 4 s. Results:(1)This rotatory stimulation increased be and G(δ+θ)/(α+β)in saline-treated control animals.(2) After the adminis-tration of scopolamine, G(δ+θ)/(α+β),Gδ and Gδ/(α+β)all increased but Gδ and Gθ decreased dur-ing the rotatory stimulation.(3) In anisodamine treated animals, Gθ increased and Gα decreased only in the early period of the rotatory stimulation,while Gδ/(α+β)and G(δ+θ)/(α+β)did not change signif-icantly,(4) After the administration of methylphenidate, Gδ decreased and Gβ increased and,as a re-sult,Gδ/(α+β)and G(δ+θ)/(α+β)decreased significantly. Conclusion: These results suggest that si-nusoidal rotatory stimulation may produce inhibition of cerebral cortex as we have reported previously,which is much consistent with the inhibitory symptoms of central nervous system in motion sickness.Anisodamine and methylphenidate could offset or even reverse this inhibition process. Scopolamine will cause further inhibition of cerebral cortex and thus may be disadvantageous for motion sickness treat-ment.Whereas,methylphenidate may inhibit motion sickness through elevation of arousal level. Anti-motion sickness effects of scopolamine and anisodamine may be related to its effects on some subcortical centers as some other investigators have suggested.Comparing the central and peripheral effects of anisodamine and scopolamine,it is suggested that anisodamine may be more advantageous for anti-mo-tion sickness use than scopolamine.

关 键 词:抗运动病药 药理 脑电功率谱 运动病 

分 类 号:R965[医药卫生—药理学] R852.330.5[医药卫生—药学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象