肺炎支原体性肺炎患儿血清中IL-6、IL-10水平测定及意义  

Detection and significance of serum interleukin 6(IL-6),interleukin 10(IL-10) in children with mycoplasma pneumoniae pneumonia

作　　者：王振华[1] 李丽红[1] 于侠[1] 

机构地区：[1]长春市儿童医院,130061

出　　处：《中国妇幼保健》2005年第21期2802-2803,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨支原体性肺炎患儿血清中细胞因子的变化及意义。方法:应用酶联免疫吸附试验(ELISA)双抗体夹心法检测60例支原体性肺炎患儿急期和恢复期血清中白细胞介素6(IL-6)、白细胞介素10(IL-10)的含量,同时对57例同期健康儿童血清中IL-6、IL-10进行检测。结果:①支原体性肺炎患儿急性感染时血清中IL-6明显高于健康儿童,差异显著(P<0.01),而恢复期时血清中含量和健康儿童差异无显著性(P>0.05)。②支原体性肺炎患儿急性感染期和恢复期血清中IL-10均高于健康儿童,差异显著(P<0.01),且恢复期时血清中含量高于急性感染期。结论:细胞因子IL-6、IL-10在支原体性肺炎患儿感染中起着重要的作用,参与了其发病过程。Objective： To investigate the changes and significance of serum cytokines in children with mycoplasma pneumoniae pneumonia （MP） . Methods： The levels of serum IL -6, IL - 10 were measured by ELISA methods in 60 patients with MP by clinical diagnosis and in 57 healthy children. Results： The levels of serum IL -6 of patients in acute MP were significant higher than that of healthy children （ P 〈 0. 01 ） . But the levels of serum IL - 6 of patients in convalescence were not magnificent with that of healthy children （ P 〉 0.05 ） . The level of serum IL - 10 of patients in acute and convalescence MP were magnificent higher than that of healthy children （ P 〈 0.01 ） . But the levels of serum IL - 10 of patients in convalescence MP were magnificent higher than that of patients in acute MP. Conclusion： Serum IL -6 and IL - 10 play an important role in children with MP infection.

关 键 词：儿童 支原体肺炎 白细胞介素-6 白细胞介素-10 

分 类 号：R725.6[医药卫生—儿科]