外科手术患者血清趋化因子IP-10含量的变化及意义  

Kinetics of serum chemokine interferon-inducible protein-10 in surgical patients and its significance

作　　者：姚胜[1] 姚咏明[2] 李基业[1] 于燕[2] 

机构地区：[1]解放军总医院304临床部普通外科,北京100037 [2]解放军总医院304临床部全军烧伤研究所,北京100037

出　　处：《解放军医学杂志》2005年第10期873-874,共2页Medical Journal of Chinese People's Liberation Army

基　　金：国家重点基础研究发展规划项目(编号G1999054203);首都医学发展科研基金重点项目(编号2003-2023)资助课题

摘　　要：目的观察外科手术患者血清趋化因子IP-10含量的变化及其与脓毒症的关系.方法 14例普通外科疾病住院手术患者,根据术后是否出现脓毒症分为脓毒症组(n=6)和非脓毒症组(n=8),另有 6例健康志愿者作为正常对照组(n=6).采用ELISA法动态检测血清中IP-10含量.结果外科手术后非脓毒症患者血清IP-10含量升高,第1～3天达峰值,一周降至术前范围;手术后并发脓毒症者血清IP-10含量进一步升高且持续时间延长,术后1、3、7天显著高于无脓毒症者(P<0.05或0.01),且脓毒症组IP-10含量与白细胞计数呈显著正相关(r=0.955,P<0.05).结论外科手术打击可刺激IP-10的产生,血清IP-10水平持续升高与脓毒症的发生密切相关.Objective To investigate the clinical significance of the kinetics of serum chemokine interferon-inducible protein-10 （IP-10） levels in surgical patients, and the relationship between its kinetics and post-operative sepsis. Methods 14 surgical patients and 6 healthy volunteers were enrolled in the present study, and they were divided into three groups as follows： （1） normal control group （n=6）; （2） non-sepsis group （n=8） ; （3） sepsis group （n=6）. IP-10 levels in serum were determined by ELISA. Results In patients without sepsis, serum IP-10 levels were markedly elevated on postoperative days 1 to 3, returning to baseline level on day 7 after major operations. In surgical patients complicated by sepsis, however, senml IP-10 levels were persistently high from day postoperative 1 to 7, being significantly higher than that in patients without septic complications （P〈0.05 or 0.01）. Moreover, it was found that serum IP-10 levels were positively correlated with blood white cell counts （r=0.955,P〈0. 05）. Conclusion These data suggested that a major operation could lead to circulating IP-10 release, and senml IP-10 levels appeared to be associated with the development of sepsis following major surgical operations.

关 键 词：外科手术 干扰素诱导蛋白10 脓毒症综合征 

分 类 号：R644[医药卫生—外科学] R631.1[医药卫生—临床医学]