不同NA亚型H5禽流感疫苗在鸭群的免疫效力及母源抗体对免疫效力的影响  

Comparison of Protective Efficacy of H5N2 and H5N1 Subtype Inactivated Oil-emulsion Vaccine against H5N1 Avian Influenza Virus (AIV) in Ducks and Effects of Maternal Antibody on Immune Responses

作　　者：张评浒[1] 唐应华[1] 刘晓文[1] 薛锋[1] 仇旭升[1] 曹永忠[1] 高崧[1] 吴艳涛[1] 刘秀梵[1] 

机构地区：[1]扬州大学农业部畜禽传染病学重点开放实验室,江苏扬州225009

出　　处：《中国家禽》2005年第20期8-11,共4页China Poultry

基　　金：国家科技攻关计划项目(2004BA519A02)

摘　　要：研究以H5N2和H5N1两种油乳灭活疫苗免疫鸭群对高致病性禽流感H5N1AIV的攻毒保护效力进行了比较。结果表明,在同等免疫剂量下,从发病率、死亡率和泄殖腔排毒规律三项指标综合评价来看,H5N1疫苗免疫组对高致病性禽流感H5N1流行株攻毒的保护效率较H5N2免疫组理想,故针对高致病性禽流感H5N1流行的情况,宜采用H5N1禽流感疫苗。水禽禽流感母源抗体对灭活苗免疫具有一定的干扰作用。In this study,protective efficacy of H5N2 and H5N1 subtype inactivated oil-emulsion vaccine against H5N1 avian influenza virus in ducks was evaluated.The results showed that based morbidity, mortality,protective efficacy,the protective effects of duck flocks immunized with HSN1 is better than that of H5N2 under the same immune dose, and the presence of maternal antibody could interfere with bird＇s active immunization.

关 键 词：NA亚型H5禽流感 疫苗 鸭群 免疫效力 母源抗体 发病率 死亡率 泄殖腔排毒规律 

分 类 号：S858.32[农业科学—临床兽医学] S852.5[农业科学—兽医学]