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机构地区:[1]军事医学科学院毒物药物研究所,北京100850
出 处:《药学学报》2005年第10期931-934,共4页Acta Pharmaceutica Sinica
摘 要:目的研究狭叶山胡椒根中的生物碱成分。方法采用硅胶、MC I-DHP-20P反相填料柱色谱进行分离,通过MS,1H NMR,13C NMR,HMQC,HMBC等波谱方法进行结构鉴定,同时采用半合成方法确证结构。结果共分离得到7个生物碱类化合物,分别为樟苍碱(I)、N-甲基樟苍碱(II)、波尔定(III)、异波尔定(IV)、降波尔定(V)、m agnocurarine(V I)、N-乙氧甲酰基樟苍碱(V II),通过合成方法验证了N-乙氧甲酰基樟苍碱的化学结构。结论所有化合物皆首次从该植物中分得,其中N-乙氧甲酰基樟苍碱为首次从自然界分离得到。Aim To study the alkaloid constituents of the root of Lindera angustifolia Cheng. Methods The constituents were isolated and purified by column chromatography and the structures were characterized by spectral analysis. Results Seven aporphine alkaloids, laurotetanine (Ⅰ), N- methyllaurotetanine ( Ⅱ), boldine ( Ⅲ), isoboldine ( Ⅳ), norboldine ( Ⅴ), N- ethoxycarbonyllaurotetanine (Ⅶ) and a quaternary isoquinohne alkaloid, magnocurarine (Ⅵ), were isolated and identified. The structure of Ⅶ was further identified by semi-synthesis with Ⅰas starting material. Conclusion All compounds were obtained from this plant for the first time and compound Ⅶwas found as a naturally occurring compound for the first time.
关 键 词:狭叶山胡椒 生物碱 N-乙氧甲酰基樟苍碱
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