新合成化合物哌嗪雌酚酮对老年大鼠骨代谢的作用  

Piperazinyl Estrone, a New Estrogen Derivant,Prevents Bone Loss in Aged Rats

作　　者：武晓蓉[1] 李青南[2] 翁玲玲[3] 郑虎[3] 

机构地区：[1]广东药学院药理教研室,广州510224 [2]广东医学院骨生物学研究室,湛江524023 [3]四川大学华西药学院药物合成室,成都610041

出　　处：《生物医学工程学杂志》2005年第1期50-52,共3页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 (3 943 0 12 0 )

摘　　要：研究新合成化合物哌嗪雌酚酮对老年雌性大鼠骨代谢及子宫的影响。 32只 2 2月龄 SD大鼠 ,随机分为4组 :对照组 (生理盐水 0 .1m l/ kg/ d) ,哌嗪雌酚酮高、中、低剂量组 (2、1和 0 .5 mg/ kg/ d) ,皮下注射 30 d。取胫骨上段制成不脱钙骨制片作骨形态计量学测量分析 ,同时取子宫称重。结果表明 ,与对照组比较 ,哌嗪雌酚酮组骨量增加 ,其中中剂量组骨形成呈增加趋势 ,骨吸收显著降低 ,骨量增加最明显 ;子宫重量无明显变化。我们的结果提示 :哌嗪雌酚酮可预防老年大鼠骨质减少 ,中剂量组效果最明显。且未见明显刺激子宫的副作用。The purpose of this study was to determine the effects of piperazinyl estrone, a new estrogen derivative, on bone turnover, bone mass and uterine weight in female aged rats. Thirty-two Sprague-Dawley female rats at the age of 22 months were treated with vehicle or with piperazinyl estrone （P-E） at 0.5, 1 and 2 mg/kg /day, subcutaneous injection for 1 month. At the time of death, the uterine weight was measured and bone histomorphometric analysis of proximal tibial metaphyses （PTM）was performed in undecalcified sections. Compared with control, bone mass was increased in P-E groups. Dynamic data showed that bone resorption were decreased, but bone formation was not declined and bone mass was increased significantly in P-E （1 mg/kg day） group. There was no significant change in uterine weight. The findings of this study show that piperazinyl estrone at dosage of 1mg/kg/d is most efficacious in preventing the bone losses in aged rats and has no side effect on uterus.

关 键 词：合成化合物 哌嗪雌酚酮 老年 大鼠 骨代谢 

分 类 号：R965[医药卫生—药理学]