不同应力环境下生长期大鼠股骨的生物力学试验研究  

Biomechanical Test Study of Rat Femurs Growing Under Different Stress Environment

作　　者：刘迎曦[1] 赵文志[1] 张军[1] 李守巨[1] 李靖年[2] 孙晓江[2] 

机构地区：[1]大连理工大学工程力学系工业装备结构分析国家重点实验室,大连116024 [2]大连医科大学第二临床学院骨科,大连116023

出　　处：《生物医学工程学杂志》2005年第3期472-475,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(10472025);辽宁省自然科学基金资助项目(20032109)

摘　　要：在同一动物个体中创造两种应力环境,对不同受力条件下生长的大鼠股骨进行三点弯曲试验和压缩试验,研究应力对骨力学性能的影响。切断大鼠右侧坐骨神经,使其右后肢废用,为废用组;其左后肢处于过度负荷状态,为过载组;正常大鼠为对照组。每天早、午、晚鼓励动物运动各0.5h,4周时结束实验观察,测试股骨干的生物力学参数。结果显示:应力环境引起大鼠股骨若干力学参数的改变。本研究表明,活骨组织可以通过改变其力学性能来适应环境,本实验模型实用可靠。By creating two kinds of stress environment in the same animal model, we performed a three-point bending test and a compressing test on the rat femurs growing under different stress conditions to characterize the effect of stress on bone mechanical properties. The right hindlimbs were subjected to sciatic nerve resection to become cripple and were used as unloading group; the left hindlimbs bore excess load and made up the overloading group; the normal rats were used as control group. The animals were encouraged to exercise for half an hour everyday in the morning, noon and evening. The experiment observation finished in four weeks. The biomechanical parameters of femur diaphyses were measured. The experiment results showed that stress environment may change several mechanical parameters of rat femurs. This study indicated that bone tissues can adapt to its stress environment by changing its mechanical properties. The experimental model in this article is practical and reliable.

关 键 词：应力环境 生长期 大鼠 股骨 生物力学 骨质疏松 

分 类 号：R318.01[医药卫生—生物医学工程]