磺脲受体1基因多态性与2型糖尿病相关性家系研究  

Correlation between sulfonylurea receptor 1 gene polymorphism and type 2 diabetes mellitus

作　　者：汪纯[1] 吴国亭[1] 于永春[1] 滕小洪[1] 王吉影[1] 李文君[1] 韩玉麒[1] 顾耀[1] 王艳波[1] 

机构地区：[1]同济大学第十人民医院内分泌代谢科,上海200072

出　　处：《中华内分泌代谢杂志》2005年第5期446-447,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目(30270632)

摘　　要：依据传递不平衡法(TDT)对上海地区55个2型糖尿病家系进行磺脲受体1(SUR1)基因多态性分析及临床表型联系分析,未发现SUR1基因的多态性和突变与上海地区2型糖尿病连锁的证据,但其对胰岛素、C肽水平有一定影响。The association of the sulfonylurea receptor 1 gene variant with type 2 diabetes mellitus was analyzed in 55 families in Shanghai by transmission/disequilibrium test. The sulfonylurea receptor 1 gene variant was not linked with type 2 diabetes mellitus, but was associated with insulin and fasting C-peptide.

关 键 词：磺脲受体1 基因多态性 2型糖尿病 遗传因素 胰岛素 

分 类 号：R587.1[医药卫生—内分泌]