成骨细胞响应机械刺激的力化学转导机理  

The Mechanotransduction Mechanism of How Osteoblasts Respond to Mechanical Stimulation

作　　者：王远亮[1] 唐丽灵[1] 王建华[1] 蔡绍皙[1] 

机构地区：[1]重庆大学生物工程学院生物力学与组织工程教育部重点实验室,重庆400044

出　　处：《生物医学工程学杂志》2005年第2期400-402,412,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 (19872 0 80 )

摘　　要：应力环境可调节骨组织的生长、吸收和重建。在细胞水平上,机械刺激可以影响成骨细胞的生理活性,如增殖、碱性磷酸酶活性、骨钙素合成等。力转导是将生物物理力转化为细胞的生化响应的过程,它是许多生理功能的基础,早期响应基因(c- fos,c- jun) ,第二信使系统(Ca2 + ,NO,c AMP) 。The stress environment regulates the factors of growth, resorption and remolding in bone tissue. Mechanical stimulation at cell physical level affects the physiological activity of osteoblasts, including proliferation, ALP activity and osteocalcin production. Mechanotransduction is a procedure which transduces the biophysical force into biochemical responses. It is also the basis of many physiological functions. The early response genes （c-los, c-jun）, the second message systems（Ca^2＋ , NO, cAMP）and the mechano-sensitive cation channel are involved in the mechanotransduction course when osteoblasts respond to the mechanical stimulation.

关 键 词：成骨细胞 应力 力转导 机械刺激 响应 转导 化学 碱性磷酸酶活性 机理 第二信使系统 

分 类 号：R318.01[医药卫生—生物医学工程]