环孢素和舒莱单一或联合应用对大鼠同种异体心脏移植抗排斥的作用  

Effect of cyclosporine and simulect mono and combination therapy on cardiac allo-transplantation in rats

作　　者：熊海波[1] 夏穗生[2] 黄祖发[1] 叶启发[1] 温浩[3] 

机构地区：[1]中南大学湘雅三医院器官移植研究院,长沙410013 [2]华中科技大学同济医学院器官移植研究所,武汉430030 [3]新疆医科大学第一附属医院普外科,乌鲁木齐830054

出　　处：《中南大学学报（医学版）》2005年第5期549-552,共4页Journal of Central South University ：Medical Science

摘　　要：目的:观察环孢素A和舒莱单一或联合用药对大鼠同种异体心脏移植的作用,评价联合用药的药效。方法:不同剂量环孢素A和舒莱单一或联合用于大鼠心脏移植,术后观察移植心存活时间,取移植心行病理组织学检查,检测血清IL-2和IL-4水平。结果:单一及联合用药均能延长移植心的存活时间,而且移植心存活时间越长,其发生排斥反应的程度就越轻。在急性排斥时血清IL-2水平明显升高,而移植心长期存活者IL-4水平明显升高。结论:环孢素A和舒莱可有效地抑制同种异体的移植排斥反应,联合应用有明显的协同作用。Objective To observe the effect of cyclosporine and simulect mono or combination therapy on cardiac allo-transplantation in rats. Methods Recipients with allografts were treated with different doses of eyelosporine and/or simulect after cardiac allo-transplantation. Graft survival time was observed; the histopathologieal examination of graft tissues was performed; and levels of serum IL-2 and IL-4 were determined. Results Mono or combination therapy with eyelosporine and/or simuleet increased the survival of cardiac allografts. With the prolongation of survival time of the grafts, the rejection of grafts was moderated. The serum IL-2 level increased in acute rejected grafts; the serum IL-4 level increased evidently in long survival grafts. Conclusion Cyclosporine and simuleet have an effect in the prolongation of cardiac allograft survival in rats,and the combination therapy shows an evident synergistic effect.

关 键 词：环孢素A 舒莱 协同作用 心脏移植 免疫耐受 排斥反应 大鼠 

分 类 号：R654.2[医药卫生—外科学]