白松片对应激大鼠行为及大脑皮质NE,DA的影响  

Effects of baisong tablets on the behavior and levels of norepinephrine and dopamine in the brain of stress rats

作　　者：宋炜熙[1] 胡随瑜[1] 黄川原[1] 陈昌华[1] 王哲[1] 

机构地区：[1]中南大学湘雅医院中西医结合研究所,长沙410008

出　　处：《中南大学学报（医学版）》2005年第5期574-578,共5页Journal of Central South University ：Medical Science

基　　金：国家"十五"科技攻关项目(2001BA701A22)

摘　　要：目的:探讨中药白松片对应激大鼠行为及大脑皮质去甲肾上腺素(NE)、多巴胺(DA)含量的影响。方法:将健康成年雄性大鼠40只,随机分为正常组、模型组、氟西汀组及白松片组。通过慢性轻度不可预见性应激配合单居复制抑郁模型。采用预防加治疗给药,观察敞箱试验得分、摄食量、糖水消耗量及体质量变化;高效液相色谱仪法检测大脑皮质NE,DA的含量。结果:白松片试验组敞箱试验得分、蔗糖水消耗量、体质量增加及大脑皮质NE,DA含量均高于模型对照组(P<0.05或P<0.01)。结论:白松片可改善应激大鼠抑郁行为,提高大脑皮质NE,DA的含量。Objective To explore the effects of baisong tablets on the behavior and contents of norepinephrine and dopamine in the brain of stress rats. Methods Forty adult Sprague-Dawley male rats were randomly divided into 4 groups： the control group, the depression model group, the baisong tablet group and the fluoxetine group. The depression model was replicated by chronic unpredictable mild stress and single house in 21 days. Ten rats as a group were treated with baisong tablets or fluoxetine hydrochloride. Changes of behaviors were observed by open-field test and the volume of sugar-solution the rat drank in 24 hours. The weight increase was also observed. The levels of norepinephrine and dopamine in the brain in each group were detected with high-pergomanee liquid chromatography. Results Compared with the model group, baisong tablets could improve the depressive behaviors significantly, and increase the levels of norepinephrine and dopamine in the rat brain. Conclusion Baisong tablets can improve the depressive behaviors and increase the levels of 5-hydroxytryptaimne and dopamine in the brain of stress rats.

关 键 词：白松片 应激 行为 去甲肾上腺素 多巴胺 

分 类 号：R285[医药卫生—中药学]