^(18)F-FET与^(18)F-FDG PET显像对照研究  

A preliminary study of ^(18)F-FET PET tumor imaging in comparison with ^(18)F-FDG PET

作　　者：霍力[1] 周前[1] 党永红[1] 崔瑞雪[1] 

机构地区：[1]中国医学科学院,中国协和医科大学北京协和医院PET中心,100730

出　　处：《中华核医学杂志》2005年第5期267-269,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的探讨O-(2-[18F]氟代乙基)-L-酪氨酸(18F-FET)对肿瘤的探测能力。方法2 例脑瘤患者,用于了解18F—FET PET显像的全身分布情况。经病理检查或手术证实的其他部位肿瘤患者12例(肺癌6例,胰腺癌、神经内分泌肿瘤各2例,肾上腺皮质癌、鼻咽癌各1例),均有近期CT 检查,少数行MRI或全身骨显像检查,1周内分别行18F-FET与18F-脱氧萄萄糖(FDG)PET显像。结果①18F—FET主要经泌尿及胆道系统排泄,骨骼、软组织及心、肝等仅轻度摄取,标准摄取值(SUV) 0.38-1.64,肠道、胰腺基本不显影。②12例肿瘤患者18F—FDG PET显像共检出110个病灶,18F—FET 仅检出15个,病灶的SUV也明显低于18F-FDG。18F-FET不仅对一些18F—FDG代谢活性高的孤立病灶显示不清,对小病灶的检出率也明显低于18F-FDG。结论18F—FET PET显像对肺癌、胰腺癌、肾上腺皮质癌等的探测能力明显低于18F—FDG。Objective To study the detectability of O-2-^18 F-fluoroethyl-L-tyrosine （^18F-FET） for tumor diagnosis, Methods 2 brain tumor patients underwent ^18F-FET PET whole body scan. 12 cases（6 lung carcinoma, 2 neuroendocrine carcinoma, 2 pancreatic carcinoma, 1 adrenal cortical carcinoma and 1 nasopharyngeal carcinoma） underwent both ^18 F-FET and ^18 F-fluorodeoxyglucose （FDG） PET studies within 6 days. All patients were performed CT scan and some with MRI and ^99Tc^m-methylene diphosphonic acid （MDP） bone scan. All diagnoses were proved by pathology in 10 cases and operation in 2. Results ①^18F- FET whole body scan showed that ^18F-FET was mainly excreted through hepatobililary and urinary system. There were slight uptakes in muscles, bones, mediastinum, heart and spleen etc. Lung had a little uptake. No uptake was revealed in intestine and pancreas, ②110 lesions were identified by ^18F-FDG PET, while only 15 were detected by ^18F-FET PET（ 14% ）. The standardized uptake value （SUV） of ^18F-FET was also far less than ^18F-FDG. Not only it was tar less clearly visualized to those hypermetabolic ^18F-FDG solitary nodules, but also the detectability of small lesions significantly lowered. Conclusion ^18F-FET PET imaging was less detectable for lung, pancreas, adrenocortical tumor than ^18F-FDG.

关 键 词：肿瘤 体层摄影术 发射型计算机 酪氨酸 脱氧葡萄糖 对比研究 ^18F-FDGPET显像 ^18F-FET 对照研究 肾上腺皮质癌 神经内分泌肿瘤 

分 类 号：R817[医药卫生—影像医学与核医学]