^(99)Tc^mO_4^-动态显像在颌下腺移位术中的临床应用  

The clinical study of the value of ^(99)Tc^mO_4^- dynamic scintigraphy in submandibular gland transloca-tion in nasopharyngeal carcinoma patients

作　　者：樊卫[1] 王国慧[1] 刘学奎[2] 曾宗渊[2] 

机构地区：[1]中山大学肿瘤防治中心核医学科,广州510060 [2]中山大学肿瘤防治中心头颈外科,广州510060

出　　处：《中华核医学杂志》2005年第5期301-303,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的探讨颌下腺动态显像在鼻咽癌颌下腺移位术中的临床价值。方法70例鼻咽癌初诊患者,分为试验组36例,非试验组(对照组)34例。对照组直接行常规放疗;试验组于术前1天行颌下腺99TcmO4-动态显像,根据结果选取功能较好一侧颌下腺于第2天行颌下腺移位术,术后复查颌下腺功能及择期行常规放疗。放疗后皆行颌下腺99TcmO4-动态显像及记录患者口腔干燥症状的程度, 结果采用非参数秩和检验进行统计分析。结果移位侧颌下腺功能于术后、放疗后损伤明显减轻,与非移位侧颌下腺差异有显著性(P<0.01);试验组中度以上口腔干燥症率为13.9%,对照组为76.5%, 差异有显著性(P<0.01)。结论99TcmO4-颌下腺动态显像可准确、灵敏地评估颌下腺功能。Objective To investigate the clinical value of ^99Tc^mO4^- scintigraphy in submandibular gland translocation in nasopharyngeal carcinoma （ NPC ） patients. Methods Seventy NPC cases were divided into experimental group （36 cases） and control group （34 cases）. The control group underwent routine radiotherapy directly. The experimental group was examined by radionucllde dynamic scintigraphy with ^99Tc^mO4^- 1 d before submandibular gland translocation. Based on the SPECT images, the better functioning submandibular gland was chosen to translocate next day. ^99Tc^mO4^- submandibular gland scintigraphy was repeated and radiotherapy started. The radiation induced xerostomia symptom of the patients was recorded. All data were statistically analyzed by Wilcoxon rank sum test. Results The radiation induced injury of translocated submandibular gland was significantly lowered. The functions of translocated submandibular gland and non-translocated one had significant difference after radiation （ P 〈0. 01 ）. Only 13.9% of the patients in the experimental group showed moderate or severe degree of xerostomia, whereas control group was 76. 5% , also showed a statistical difference between them （ P 〈 0. 01 ）. Conclusion ^99Tc^mO4^- dynamic imaging of submandibular gland can accurately and sensitively evaluate its function after translocation.

关 键 词：鼻咽肿瘤 颌下腺 手术中监测 放射性核素显像 高锝酸盐 放射疗法 ^99Tc^mO4^- 颌下腺功能 动态显像 移位术 

分 类 号：R817.4[医药卫生—影像医学与核医学]