碱性成纤维细胞生长因子在肌腱组织工程中的应用  

THE APPLICATION OF BASIC FIBROBLAST GROWTH FACTOR IN TENDON TISSUE ENGINEERING

作　　者：郝鹏[1] 项舟[1] 杨志明[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2005年第11期915-918,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金重点资助项目(30271317)~~

摘　　要：目的综述近年来碱性成纤维生长因子(basicfibroblastgrowthfactor,bFGF)在组织工程肌腱相关研究中的进展。方法广泛查阅国内外相关文献,进行整理、综合与分析。结果bFGF在促进组织工程肌腱标准细胞系的建立,诱导支架材料的合成与降解,增强细胞与支架材料之间的相互作用,加速组织工程材料的再血管化等方面均有明显作用。结论促进内源性bFGF合成、控释外源性bFGF及提高bFGF的生物利用度等方面取得的进展,为bFGF在组织工程中的应用开辟了良好的应用前景。Objective To review the recent researches of basic fibroblast growth factor （bFGF） in tendon tissue engineering, Methods Recent original related literature was extensively reviewed and analyzed, Results bFGF played an important role in establishing standard tendon tissue engineering cell lines, inducing the compound and analysis of extracellular matrix, enhancing interactions between cells and extracellular matrix and accelerating tissue engineering materials＇ neovascularization. Conclusion The progresses in increasing endogenetic bFGF expression, controlling the release of exogenous bFGF and improving the bio-utilization of bFGF has laid foundation for wider use of bFGF in tendon tissue engineering.

关 键 词：组织工程 碱性成纤维细胞生长因子 肌腱 

分 类 号：R318.0[医药卫生—生物医学工程]