益心口服液对大鼠急性心肌梗塞范围及血液流变学的影响  

Effects of Yixin Oral Liquid on Myocardial Infarct Size and Hemorheology in Rats with Acute Myocardial Ischemia

作　　者：睢大篔[1] 吕忠智[1] 于晓凤[1] 王黎[1] 

机构地区：[1]白求恩医科大学药理教研室

出　　处：《中国实验方剂学杂志》1996年第3期14-16,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：益心口服液８、１６ｇ／ｋｇ连续ｉｇ５ｄ，对结扎左冠状动脉前降支（ＬＡＤ）产生急性心肌梗塞２４ｈ大鼠，能显著缩小心肌梗塞范围，降低血清ＣＫ和ＬＤＨ活性，亦能降低全血高切变率及低切变率粘度，全血高切变率及低切变率还原粘度，血浆粘度，红细胞聚集指数，红细胞刚性指数，红细胞电泳时间。而红细胞压积，纤维蛋白原浓度，血沉及血况方程常数则无明显改变。４ｇ／ｋｇ组对上述指标无明显影响。Effect of Yixin oral liquid on Tnyocardial infarct size and hemorheology were studied in rats with acute myocardial ischemia,The results showed that the liquid at a dosage of 8 or 16g/kg,ig×5d could significantly reduce the size of myocardial in-farcts and decline serum CK and LDH activities at 24h after ligation of LAD. It could also decrease ηBH、ηBL、ηBHR、ηBLR、ηP、ERI、RCET、whereas HCT、Fib、ESR and EEC were not changed markedly.Yixin at a dosage of 4g/kg had no significant ef-fects on theabove parameters.

关 键 词：益心口服液 中药 心肌梗塞 血液流变学 药理 

分 类 号：R285.5[医药卫生—中药学] R259.422.2[医药卫生—中医学]