中西药联用提高心肺脑复苏成功率的临床研究  

Improving successful rate of cardiac pulmonary cerebral resuscitation by using traditional and western medicine

作　　者：许荣廷[1] 宋慧玲[2] 何旭东[1] 胡俊霞[1] 隋文娟[1] 李丽[1] 王芦敏[1] 赵志伦[1] 

机构地区：[1]山东大学第二医院急症科,山东济南250033 [2]山东大学第二医院内分泌科,山东济南250033

出　　处：《山东大学学报（医学版）》2005年第9期791-794,共4页Journal of Shandong University:Health Sciences

基　　金：山东省中医管理局科技发展重点项目科研资金资助课题(项目编号:2002-2-26)

摘　　要：目的:探讨中西药联用提高心肺脑复苏的成功率。方法:随机将69例心搏骤停经心肺复苏心脏复律的患者分为试验组(35例)和对照组(34例),心肺复苏抢救措施和急救药物均按常规应用。试验组在心脏复律后即刻或进一步在生命支持阶段早期联合应用生脉注射液+磷酸肌酸针剂静脉滴注,1次/d,一般应用3～7d。结果:①两组病例≤5min开始心肺复苏者,心肺脑复苏成功率最高,6～10min次之,虽11～15min仍有可能复苏成功,但组间比较无统计学意义(P=0.05);②各种原因所致的心搏骤停中,试验组心肺脑复苏成功率高于对照组(62.9%vs32.4%,P<0.01);③对试验组和对照组在各个时间段的心肺脑复苏成功病例数进行比较,差异具有统计学意义(P<0.05);④两组间心率/节律、mBp、O2max、心肌酶谱、血液生化、肝/肾功能、血气分析与酸碱平衡、WBC与N%等项指标达到稳定/或者平衡的时间进行比较,差异具有统计学意义(P<0.05)。结论:在心搏骤停即刻或者进一步生命支持阶段联合应用生脉注射液和磷酸肌酸针剂,确有维护心脏和循环功能、提高心肺脑复苏成功率的良好疗效。Objective： To observe the effect of traditional Chinese medicine combined with western medicine in increasing the successful rate of cardiac pulmonary cerebral resuscitation （CPCR）. Methods： Sixty-nine cases performed cardiac pulmonary resuscitation （CPR） on sudden cardiac arrest （SCA） were randomly divided into two groups, test group （35 cases） and contrast group （34 cases）. Both groups were treated with common therapeutics based on the CPR and ECC （emergency cardiovascular care） guidelines 2000, and the test group furthermore was treated with sheng-mai injection plus creatine phosphate（CP） once a day for 2- 7 days in early prolonged life support （PLS） phase. Results： ①The highest successful rate of CPR occurred when SCA ≤5 minutes ,the second occurred when 6 minutes≤SCA ≤ 10 minutes, but the successful rate of CPR was not significantly different when 11 minutes≤SCA≤ 15 minutes; ② the successful rate of CPCR in test group was 62.9%（22/35）, and in contrast group was 32.4%（11/34） （P 〈 0.01）; ③the successful CPCR in various phases of PLS had significant difference between the two groups （P 〈 0.05）; ④ the stable or balanced state of HR/rhythm,mBp,O2max,cardiac enzymology,serum chemical composition,liver and renal function,blood gas/acid and basic balance,WBC and N% had statistic significance in time （P 〈 0.05）. Conclusion： Shengmai injection plus CP have obvious theraputic efficiency on protecting the heart function and supporting good circulation state ,and can increase the successful rate of CPCR.

关 键 词：生脉注射液 磷酸肌酸 心肺脑复苏 成功率 

分 类 号：R541.78[医药卫生—心血管疾病]