SLE血小板聚集功能及茶黄烷醇类物质对其影响  

TheFunctionofPlateletAggregationinSLEandtheEfectofTeaFlavanols

作　　者：徐根波[1] 李翠琴[1] 孙国均[1] 

机构地区：[1]浙江医科大学附属第二医院

出　　处：《中华皮肤科杂志》1996年第4期237-239,共3页Chinese Journal of Dermatology

摘　　要：６０例ＳＬＥ患者血小板自发聚集率和花生四烯酸、二磷酸腺苷诱导的聚集率较正常人明显升高（Ｐ＜０．０１），尤以活动期、伴肾损害和补体下降者为甚。血小板自发聚集率与循环免疫复合物增高呈正相关，提示其可作为ＳＬＥ患者高凝状态的观察指标之一。茶黄烷醇类物质能抑制各种诱导剂诱导的ＳＬＥ患者血小板的聚集，且随着浓度增加而增加，并能提高聚集后血浆环磷酸腺苷水平，提示茶黄烷醇类物质可能作用于前列腺素代谢的中间环节，对ＳＬＥ伴高凝状态的治疗具有一定价值。Therateofplateletspontaneousaggregationandtherateofaggregationinducedbyarachidonicacid(AA),andadenosinediphosphate(ADP)in60patientswithSLEweresignificantlyhigherthanthoseincontrols(P<0.01),especialyinthoseofprogresivestage,withrenallesionandhypocomplementemia.PlateletspontaneousaggregationratewaspositivelycorrelatedwithincreasedCICwhichsuggeststhatthespontaneousaggregationratecouldbeusedasoneoftheindexesforhyper-coagulationstateinSLE.Inaddition,itwasfoundthatteaflavanolscouldinhibitplateletaggregationinducedbyADP,adrenalineandAAinpatientswithSLE.Theefectofteaflavanolsincreasedwithin-creasingconcentrations,andcouldincreaseplasmacAMPlevelafterplateletaggregation.Itsuggeststhatteaflavanolsmayexertanactiononthemetaboliclinkinprostaglandins,andbeofvalueforthetreatmentofSLEpatientscomplicatedwithhypercoagulationstate.

关 键 词：系统性红斑狼疮 血小板聚集 茶黄烷醇类物质 

分 类 号：R593.241[医药卫生—内科学]