黄芪对大鼠缺氧性肺动脉高压功能形态学的影响  

TheinhibitoryeffectsofRadixAstragalionhypoxicpulmonaryhypertensionofrats

作　　者：席思川[1] 阮英茆[1] 张连庄 司文学[1] 

机构地区：[1]北京中国医学科学院阜外心血管病医院病理科

出　　处：《中华病理学杂志》1996年第4期236-238,共3页Chinese Journal of Pathology

摘　　要：为观察黄芪对缺氧性大鼠腺泡内肺动脉构形重组和肺动脉高压是否具有阻抑效应，以期为该药在肺动脉高压的防治方面提供实验依据。在常压低氧条件下，选用６０只大鼠，分低氧组、低氧加黄芪组和正常组，在实验第１５天、３０天分别测量右心室收缩压，计算右心室肥大指数、光镜与电镜观察肺血管病变及进行显微形态计量学检测，动态观察了黄芪对低氧大鼠腺泡内肺动脉构形重组及肺动脉高压的影响。结果显示黄芪不仅能拮抗缺氧性腺泡内肺动脉收缩，减轻低氧对肺动脉壁细胞的损伤，还能阻抑腺泡内肺动脉中膜肌化增强和外膜纤维母细胞增生。说明黄芪有明显阻抑低氧性腺泡内肺动脉构形重组和预防缺氧性肺动脉压升高的作用。TheinhibitoryefectsofRadixAstragali(RA)onhypoxicstructuralremodelingofin-tra-acinarpulmonaryarteries(IAPA)andpulmonaryhypertension(PHT)werestudiedinrats,whichwerefedinhypoxicenvironmentundernormalatmosphericpressure(10%O210hours/day).60ratsweredi-videdinto3groups;hypoxiagroup,hypoxia+RAgroupandcontrolgroup.Onthe15thand30thdayofhypoxia,rightventricularsystolicpressure(RVSP)andrightventriclehypertrophyindex(RVHI)weremeasuredandpulmonaryvesselchangeswerestudiesunderlightandelectronicmicro-scopesandmor-phometricanalysis.Comparedwiththehypoxia+RAgroup,RAcouldpreventIAPAwalceldamageanddilatetheconstrictedIPIAinducedbyhypoxia.RAcouldalsoinhibithypertrophicchangesinthetu-nicamediaandproliferationofadventitialcelsoftheIAPAandmuscularizationofnon-musculararter-ies.Therefore,preservingtheIAPAwalcelsanddilatingIAPAbyRAmayplayanim-portantroleininhibitingstructuralremodelingofIAPAandpulmonaryhypertension.

关 键 词：肺动脉高压 缺氧 黄芪 中药 防治 

分 类 号：R285.5[医药卫生—中药学] R259.432[医药卫生—中医学]