调脂治疗对老年冠心病患者胰岛素抵抗的影响  

Effects of blood lipid regulation therapy on insul in resistance in elderly patients with coronary heart disease

作　　者：陈雯[1] 郭进[1] 

机构地区：[1]广西壮族自治区人民医院干部病房,南宁530021

出　　处：《广西医学》2005年第9期1346-1347,共2页Guangxi Medical Journal

摘　　要：目的探讨老年冠心病(CHD)伴高脂血症患者在调脂治疗的同时对胰岛素抵抗的影响.方法对41例老年冠心病伴高脂血症患者服用血脂康调脂治疗前、后测定血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FBG)、空腹胰岛素(FINS),胰岛素敏感指数(ISI).结果调脂治疗前、后比较:治疗后TC、TG、LDL、FINS降低(P＜0.05～0.001),HDL、ISI升高(P＜0.05～0.01),FBG无显著性改变.TC、TG、LDL与FINS呈正相关(P＜0.01),与ISI呈负相关(P＜0.01);HDL与FINS呈负相关(P＜0.01),与ISI呈正相关(P＜0.01).结论老年冠心病伴高脂血症患者存在胰岛素抵抗.血脂康在调脂治疗的同时,可降低FINS及提高ISI,改善胰岛素抵抗.Objective To explore the effects of the blood lipid regulation therapy on insulin resistance in eldedy coronary heart disease （CHD） patients with hyperlipidemia.Method The study was carried out for 41 cases of elderly CHD patients with hyperlipidemia.The patients were taking Xuezhikang to regulate the blood lipid. Fasting serum total cholesterol （TC）, triglyeeride （TG）, higli-density lipoprotein cholesterol （HDL）, low-density lipoprotein cholesterol （LDL）,plasma glucose （FBG）, insulin （FINS）, insulin-sensitivity index （ISI） were tested before and after the blood lipid regulation therapy to compare. Results after the therapy, TC, TG,LDL,FINS lowered （ P 〈 0.05 ～ 0.001） ; HDL, ISI increased （ P 〈0.05 ～ 0.01） ;FBG showed no observable changes.TC,TG and LDL had the positive correlations with FINS （ P 〈 0.01） and the negative correlations with ISI （ P 〈 0.01 ）. HDL had a negative correlation with FINS （ P 〈 0.01 ） and a positive correlation with ISI （ P 〈 0.01）.Conduslons The insulin resistance were occurring in the elderly CHD patients with hypedipidemia. While regulating blood lipid,Xuezhikang could markedly decrease FINS and increase ISI,as well as relief the insulin resistance.

关 键 词：冠心病 高脂血症 调脂治疗 胰岛素抵抗 

分 类 号：R541.4[医药卫生—心血管疾病]