横向电场作用下外周神经兴奋特性的实验研究  

Experimental Study of Excitation of Peripheral Nerves in Transverse Electric Field Stimulation

作　　者：于辉[1] 刘雪良[1] 郑崇勋[1] 王毅[1] 

机构地区：[1]西安交通大学生物医学工程研究所,西安710049

出　　处：《生物医学工程学杂志》2005年第4期654-657,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30170257)

摘　　要：传统的外周神经电缆方程只能描述纵向电场刺激下外周神经兴奋,实验发现在脉冲磁场诱导的横向电场作用下也可使神经兴奋,从而揭示出需要进一步对感应电场兴奋外周神经的机理进行研究。本文研究了横向电场作用下外周神经的兴奋特性,以在体的人体正中神经为例研究了横向电场作用下外周神经兴奋点的位置、刺激阈值、及刺激阈值与纤维半径的关系,以离体的蟾蜍坐骨神经为例研究了刺激阈值与作用时间的关系。实验结果验证了改进的电缆方程的有效性。实验研究成果有助于磁刺激技术的进一步发展与应用。The classical cable function has been used to represent the response of peripheral nerves stimulated by external parallel electric field. Experiments show that peripheral nerves can be activated by perpendicular electric field induced by magnetic pulses, indicating that the activation mechanism needs to be thoroughly investigated. Several excitation properties of peripheral nerves in transverse-field were explored in the present paper. With a human＇s median nerve in vivo, stimulation threshold, excitation position and the relation between excitation threshold and fiber＇s radius were studied. The relation between stimulation threshold and stimulation duration was researched with sciatic nerves from toad in vitro. The experimental results verify that the modified cable function is much efficient than the classical cable function. The research will improve the nerve magnetic stimulating technique and be beneficial to further application.

关 键 词：横向电场 磁刺激 兴奋 外周神经 神经兴奋 实验研 刺激阈值 电缆方程 磁刺激技术 电场刺激 

分 类 号：R318.0[医药卫生—生物医学工程]