以PEG和PTMG为混合软段的聚氨酯的合成、表征及血液相容性研究  

Synthesis, Characterization and Blood Compatibility Studies of Waterproof Breathable Polyurethanes

作　　者：王鹏[1] 罗建斌[1] 杜民慧[1] 何成生[1] 樊翠蓉[1] 钟银屏[1] 

机构地区：[1]四川大学医用高分子及人工器官系,成都610065

出　　处：《生物医学工程学杂志》2005年第4期734-738,共5页Journal of Biomedical Engineering

摘　　要：我们用4,4'-二苯基甲烷二异氰酸酯(MDI),扩链剂1,4-丁二醇(BDO)为硬段,聚乙二醇(PEG)与聚四氢呋喃醚二元醇(PTMG)为混合软段,在不同PEG、PTMG配比下,采用二步法,合成了一系列聚醚聚氨酯(PU)。对所合成的材料进行了傅立叶变换红外光谱、力学性能测试、水接触角、吸水率、溶血试验和静态血小板粘附试验。结果表明,本研究成功合成了机械强度高、亲水性好、血液相容性良好的新型混合软段的聚氨酯,是一种有着巨大应用前景的生物医用材料。Adopting the two-step method and changing the proportion between PEG（Polyethylene glycol） and PTMG（poly （tetrahydrofuran）, we used the MDI （4,4＇-diphenylmethane diisocyanate） and short chain extender BDO（1,4-butanediol） as hard segment, the PTMG and PEG as soft segment, and hence prepared a series of polyether-based thermoplastic polyurethanes. FTIR showed the structure character of these polyurethanes. The determination of mechanics property and water contact angles revealed their good mechanics properties and hydrophilicity. Blood compatibility was evaluated by hemolysis test and platelet adhesion test, which revealed their good hemocompatibility. So those polyurethanes may be of wide application in the future.

关 键 词：聚氨酯 亲水性 血液相容性 聚醚聚氨酯 PEG 相容性研究 合成 二苯基甲烷二异氰酸酯 傅立叶变换红外光谱 生物医用材料 

分 类 号：R318.08[医药卫生—生物医学工程]