毒性比法量化判定芳烃化合物毒性类型的研究  

Investigation of the Biotoxicity Mechanism of Aromatic Hydrocarbons Quantitatively by Means of Toxicity Ratio

作　　者：董玉瑛[1] 冯霄[2] 雷炳莉[1] 

机构地区：[1]大连民族学院生命科学学院,辽宁大连116600 [2]浙江大学环境科学与工程系,浙江杭州310027

出　　处：《大连民族学院学报》2005年第5期12-14,29,共4页Journal of Dalian Nationalities University

基　　金：国家留学基金资助项目(21841013)

摘　　要：测定了苯酚、硝基苯、间硝基苯胺、对苯二胺、邻苯二酚和氯苯等6种取代芳烃化合物对发光菌(Photobacterium phosphoreum)的急性毒性,应用毒性比(TR)判定方法,同时结合分子结构特征对受试化合物毒性作用进行了探讨和分类.结果表明,氯苯为非极性麻醉型毒性机制,苯酚、硝基苯、间硝基苯胺为极性麻醉型毒性机制,对苯二胺、邻苯二酚为反应性毒性机制.Acute toxicity of six substituted aromatic hydrocarbons, phenol, nitrobenzene, m-nitroaniline, p-phenylendiamine, catechol and chlorobenzene to Photobacterium phosphoreum was determined. The above compounds were classified into groups according to the toxicity ratio （TR） and the molecular structure characters. The toxic mechanism was discussed herein. Our results showed that chlorobenzene was nonpolar anesthetic, phenol, nitrobenzene and m-nitroaniline were polar anesthetic, p-phenylendiamine and catechol were reactive toxic.

关 键 词：发光菌 取代芳烃 毒性比 毒性作用机制 类型判定 

分 类 号：X503.2[环境科学与工程—环境工程]