粥样硬化性肾动脉狭窄与冠心病及炎症相关指标的研究  

Correlation between atherosclerotic renal artery stenosis and coronary heart disease and the inflammation related factors

作　　者：蒋捷[1] 何艳 洪涛[1] 赵春玉[1] 薛林[1] 侯桂华[1] 高炜[3] 

机构地区：[1]北京大学第一医院,100034 [2]贵阳医科大学第一医院 [3]北京大学第三医院,100083

出　　处：《中国实用内科杂志》2005年第11期975-977,共3页Chinese Journal of Practical Internal Medicine

基　　金：卫生部部属医院临床学科重点项目(No.20010913)

摘　　要：目的观察粥样硬化性肾动脉狭窄与冠心病患者冠脉病变严重程度及体内炎症标志物水平的关系。方法于2002-122003-09对北京大学第一医院的163例经冠状动脉造影确诊冠心病的患者加作选择性肾动脉造影。测定血浆超敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)质量浓度。结果合并肾动脉狭窄的冠心病患者中,急性冠脉综合征(ACS)者和冠脉三支病变的比例显著增多。与肾动脉正常的冠心病患者相比,合并肾动脉狭窄者血清hs-CRP和IL-6质量浓度较高。结论肾动脉狭窄与严重冠脉病变相关,炎症状态可能是这一联系的原因之一。Objective To investigate the correlation between atherosclerotic renal artery stenosis and the severity of coronary lesions in patients with confirmed coronary artery disease and the impact of renal artery stenosis on serum inflammation related factors. Methods 163 patients from Peking University First Hospital with confirmed coronary heart disease by coronary angiography underwent selective renal artery angiography from Dec 2002 to Sep 2003. Serum hypersensitive C reactive protein （hs - C RP） and Interleukin -6 （IL -6） were measured. Results Patients combined with coronary disease and renal artery stenosis were presented with more acute coronary syndrome （ ACS ） and triple - vessel CAD. Serum hs - CRP and IL - 6 levels were also higher in this group. Conclusion Renal artery stenosis is correlated with severe coronary disease. Inflammation state could be one of the reasons for this connection.

关 键 词：肾动脉狭窄 冠心病 炎症危险因素 

分 类 号：R5[医药卫生—内科学]