2型糖尿病血清瘦素质量浓度与胰岛素抵抗的关系  

The relationship between serum Leptin concentration and insulin resistance in type 2 diabetes

作　　者：周亚茹[1] 王战建[1] 庞建华[1] 张耀[1] 

机构地区：[1]河北医科大学第三医院内分泌科,石家庄050051

出　　处：《中国实用内科杂志》2005年第11期992-993,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的探讨2型糖尿病人群血清瘦素水平与胰岛素抵抗的关系。方法2001-102002-08对河北医科大学第三医院的196例受试者(2型糖尿病者118例、对照者78名)用放射免疫法测定空腹血清瘦素水平,同时测量身高、体重、腰围、臀围。结果糖化血红蛋白(HbA1c)、收缩压(SBP)、甘油三酯(TG)和瘦素(Leptin)是影响胰岛素敏感性的因素;2型糖尿病组瘦素质量浓度高于对照组;肥胖者瘦素质量浓度显著升高,而2型糖尿病组内肥胖与非肥胖者之间瘦素质量浓度差异无显著性。结论肥胖者大多存在胰岛素抵抗;2型糖尿病人无论肥胖与否均存在一定程度的胰岛素抵抗。Objective To investigate the relationship between serum I,eptin levels and insulin resistance. Methods During 2001 - 10 -2002 -08 fasting serum Leptin concentrations were measured with RIA in 196 cases （including 118 type 2 diabetes, 78 controls）, and height, body weight were measured to calculate body mass index （BMI）. Results HbAIc, SBP, TG, Leptin were correlated with ISI, Leptin concentration were higher in type 2 diabetes than in controls; Leptin concentration was significantly increased in obese subjects, whereas in type 2 diabetes serum Leptin concentration had no significant difference between obese subjects and non - obese subjects. Conclusion Most of obeses subjects have insulin resistance, whether obesity or not, the patients type 2 diabetes have some kind of insulin resistance.

关 键 词：瘦素 肥胖 胰岛素抵抗 糖尿病 

分 类 号：R5[医药卫生—内科学]