2型糖尿病患者血清抵抗素、肿瘤坏死因子α与胰岛素抵抗的相关性研究  

Study of association between serum resistin,TNF-α and insulin resistance in type 2 diabetes mellitus.

作　　者：周竟雄[1] 李希圣[1] 陈国瑞[1] 

机构地区：[1]福建医科大学附属第二医院内分泌科,泉州362000

出　　处：《中国实用内科杂志》2005年第11期1000-1002,共3页Chinese Journal of Practical Internal Medicine

基　　金：福建省卫生厅青年科学研究基金资助项目[2003-01-12]

摘　　要：目的 探讨血清抵抗素、肿瘤坏死因子α（TNF-α）与2型糖尿病胰岛素抵抗的相关性。方法 2003-05-2004-01对福建医科大学附属第二医院的42例2型糖尿病患者及40名健康对照者，检测腰围、空腹血糖（FBG）、胰岛素、抵抗素、TNF-α等指标。结果 糖尿病组血清抵抗素、TNF-α及Homa-胰岛素抵抗指数（Homa-IR）水平显著高于对照组[（11．76．4±2．72）对（8．65±3．00）μg/L，P〈0．01]、[（0．29±0．05）对（0．19±0．04）μg／L，P〈0．01]及[（4．17±1．65）对（2．98±1．04），P〈0．01]。血清胰岛素水平前者显著低于后者[（8．91±4．72）对（12．44±4．53）mU／L，P〈0．01]。血清抵抗素水平与Homa-IR、FBG及腰围具有相关性（均P〈0．05），与TNF-α水平无相关性。血清TNF-α水平与Homa-IR显著呈正相关（P〈0．01）。结论 血清抵抗素与TNF-α参与2型糖尿病胰岛素抵抗的发生。Objective To assess the association of serum resistin, TNF -α and insulin resistance in type 2 diabetes mellitus. Methods 42 cases of T2DM and 40 cases of control were involved in the study. Their waist circumference （WC）, the levels of fasting serum resistin, TNF-α, fasting blood glucose （FBG）and fasting insulin （FINS） were measured. Results The levels of serum resistin, TNF -α and Homa - IR in T2DM group were significantly higher than those in control group, while serum FINS level was significantly lower than that in control group [ （ 11.76 ± 2.72 ） vs （8.65±3.00） μg/L, P〈0. 01 ], [ （0.29±0.05） vs （0.19±0.04） μg/L, P〈0. 01], [ （4.17±1.65） vs （2.98±1.04）, P〈0. 01] and[（8.91±4.72） vs （12.44±4.53） mU/L, P〈0. 01]. TheHoma-IR, FBG level and WC were significantly independent determinants for serum resistin level （ all P 〈 0. 05 ） ; but serum resistin level Was not significantly correlated with serum TNF - α level; serum TNF - α level was positively correlated with Homa - IR. （P 〈 0. 01 ）. Conclusion The corrlation between Homa - IR and fasting serum resistin level as well as serum TNF -α level suggests that resistin and TNF-α are involved in insulin resistance in type 2 diabetes mellitus.

关 键 词：抵抗素 肿瘤坏死因子Α 2型糖尿病 胰岛素抵抗 

分 类 号：R5[医药卫生—内科学]