尿N-乙酰-β-D-氨基-葡萄糖苷酶及尿β_2微球蛋白在过敏性紫癜肾损害早期诊断中的意义  

Clinical Significance of Combined Detecting of Urine N - Acetyl - D - Glucosaminidase and β2 Microglobulin in Early Diagnosis of Anaphylatoid Purpura Renal Injuries

作　　者：黄清明[1] 周霞[1] 谈百浓[1] 邓燕[1] 

机构地区：[1]江门市中心医院儿科,广东江门529071

出　　处：《实用儿科临床杂志》2005年第11期1110-1111,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨联合检测尿N-乙酰-β-D-氨基-葡萄糖苷酶(NAG)及尿β2微球蛋白(β2-MG)在过敏性紫癜(AP)肾损害早期诊断中的意义。方法以双夹心酶免疫法及放射免疫法检测94例AP患儿尿NAG、β2-MG水平。结果94例AP患儿中15例尿NAG异常,12例尿β2微球蛋白异常,5例尿NAG、β2微球蛋白均异常,尿NAG异常阳性率为15.96%(15/94),尿β2微球蛋白异常阳性率为12.78%(12/94);尿NAG及尿β2-MG异常的联合阳性率为28.72%(27/94),以上阳性率间两两比较:尿NAG与尿β2-MG阳性率无差异(X2=0.39P>0.05),而两者联合阳性率高于尿NAG(X2=4.41P<0.05),也高于尿β2-MG(X2=7.28P<0.05)。结论尿NAG及尿β2-MG均可作为早期诊断AP肾损害的尿标志性蛋白;应用两者联合指标,可提高其早期诊断阳性率。Objective To investigate the clinical significance of combined detecting of urine（NAG） and β2 microglobulin（β2- MG） n early diagnosis of anaphylatoid purpura renal injuries. Methods Urine NAG and β2 - MG were detected by use of rad Y and ELISA in 94 cases with anaphylatoid purpura. Results Among 94 cases, 15 cases were abnormal in urine NAG, 12 cases were abnormal in β2- MG, 5 cases were abnormal in both urine NAG and β2 - MG thus the positive ratio of urine NAG was 15.96% （15/94）, β2 - MG microglobulin 12.78 % （ 12/94）, two index together 28.72 % （ 27/94 ）. There was no significant difference between positive ratios of urine NAG and β2- MG（X^2 = 0.39 P 〉0.05 ）, but the differences reached statistical significance compared the positive ratios of two index together to urine NAG and β2 - MG （ X^2 = 4.41,7.28 P 〈 0.05 ）. Conclusions Urine NAG and β2 - MG can be used as early diagnosis index of anaphylatoid purpura renal injuries. The positive ratio would be improved under condition of combined detecting of two indexes.

关 键 词：乙酰氨基葡糖苷酶 Β2微球蛋白 紫癜 过敏性 

分 类 号：R725.5[医药卫生—儿科]