砷中毒患者红细胞免疫功能与脂质过氧化的相关关系  

Relationship between red cell immunity and lipid peroxidation of arsenism patient

作　　者：张碧霞 张爱华[2] 任渝江 胡昭宇 张彤 蒋天祥 

机构地区：[1]解放军四十四医院检验科,贵阳550006 [2]贵阳医学院预防医学系

出　　处：《中国地方病学杂志》2004年第1期16-17,共2页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金资助项目(30060077)

摘　　要：目的了解燃煤型砷中毒患者红细胞(RBC)免疫功能与脂质过氧化关系。方法将燃煤型砷中毒患者分为轻、中、重3组,选择距病区12km外的非燃用砷煤居民作对照组,分别检测各组RBC免疫功能和血浆MDA、SOD、GSH鄄Px,并分别与对照组比较。结果燃煤型砷中毒患者RBC免疫功能损伤RBC鄄ICR高于对照组,RBC鄄C3bRR低于对照组,患者MDA高于对照组,而SOD、GSH鄄Px则低于对照组。结论氧化自由基堆积造成脂质过氧化损伤,这可能是患者RBC免疫功能受损的重要原因。Objective To study the relationship between RBC immunity and lipid peroxidation of arsenism patient. Methods The activity of superoxide dismutase （SOD）, glutsthione peroxidase （GSH-Px）, malondial dehyde （MDA）, RBC-ICR and RBC-C3bRR in the blood of patients were measured and analysed. Results Compared with those of the control, the SOD, GSH-Px and RBC-C3b RR levels were lower （P 〈 0.05）, while the MDA and RBC-ICR levels were higher （P 〈 0.05）. Conclusions It is suggested that lipid peroxidation might be one of the reasons causing RBC immunity damage.

关 键 词：砷中毒 红细胞 免疫功能 脂质过氧化 谷胱甘肽过氧化物酶 

分 类 号：R599[医药卫生—内科学]