燃煤型砷中毒患者血清中9种物质放免测定及临床意义  

Serum radioimmunoassay of nine materials in patients with coal type arsenic poisoning and its clinical significance

作　　者：刘桂成[1] 董学新[1] 罗永忠[1] 黄晓欣[1] 张爱华[2] 杨大平[1] 黄建平[1] 

机构地区：[1]解放军第44医院特检科,贵阳550009 [2]贵阳医学院公卫学院预防医学系

出　　处：《中国地方病学杂志》2004年第1期77-79,共3页Chinese Jouranl of Endemiology

基　　金：全军"十五"面上基金A类资助项目(01MA048)

摘　　要：目的了解燃煤型砷中毒患者血清中9种物质水平,并探讨其临床意义。方法应用放免测定法(RIA)对患者血清叶酸、VB12、胆酸(CG)、白细胞介素素鄄2(IL鄄2)、肿瘤坏死因子(TNF)、透明质酸(HA)、Ⅳ型胶原(IV.C)、转化生长因子鄄α(TGFα)、皮质醇进行测定和分析。结果砷中毒组与对照组比较,叶酸、VB12、IL鄄2、TNF明显下降(P< 0.01),CG、HA、IV.C、TGFα明显升高(P< 0.01);皮质醇整体与对照组比较,差异无显著意义(P> 0.05);分层分析,重度组与对照组比较,差异有显著意义(P< 0.01)。结论用放免方法检测燃煤型砷中毒患者血清中上述9中物质,可以了解砷对机体的损害程度和范围,对砷中毒的临床治疗具有重要的指导作用。Objective To detect the serum levels of nine materials in patients suffered from coal type arsenic poisoning , so as to understand their clinical significance. Methods Serum contents of folic acid, vitamin B12 （VB12）, cholalic acid（CG）, interleukin（IL-2）, tumor necrosis factor（TNF）, hyaluronic acid （HA）, type Ⅳ collagen （Ⅳ-C）, transforming growth factor-α （TGFα）, and cortisol were detected by radioimmunoassay and analyzed. Results Compared with control, the serum contents of folic acid, Vit Bl2, IL-2, and TNF fell significantly （P 〈 0.01）, while the serum contents of CG, HA, Ⅳ.C, and TGFα rose significantly （P 〈 0.01 ）. There was no obvious difference （P 〉 0.05） in the serum contents of cortisol, between the arsenic group nd the control. While analyzed by delamination, there was marked difference between the serious group and the control （P 〈 0.01）. Conclusions RIA detecting of the above-mentioned nine materials in patients with coal type arsenic poisoning plays an important role in judging the range and degree of the body and in directing treatment.

关 键 词：燃煤型砷中毒 血清 放射免疫法 胆酸 白细胞介素素-2 肿瘤坏死因子 

分 类 号：R817.4[医药卫生—影像医学与核医学]