1型糖尿病患者血清sCD40L测定的临床意义  

Clinical significance of determination of sCD40L from serum of type 1 diabetes patients.

作　　者：徐邦牢[1] 王蓉[1] 贝春花[1] 雷秀霞[1] 

机构地区：[1]广州市第一人民医院,广东广州510180

出　　处：《中国热带医学》2005年第7期1432-1433,共2页China Tropical Medicine

基　　金：广州市科技计划资助项目(2004Z3-E0441)

摘　　要：目的探讨1型糖尿病无血管并发症患者血清可溶性CD40配体(sCD40L)测定的临床意义。方法用sCD40LELISA试剂盒检测1型糖尿病患者和对照组血清血清sCD40L水平。结果1型糖尿病患者和对照组血清sCD40L水平分别为2.39±0.9ng/ml及2.35±1.1ng/ml,二者比较无显著性意义(P>0.05);在所观察的变量中,1型糖尿病患者sCD40L水平与年龄正相关(r=0.53,P<0.01),而与其它变量不相关;对照组sCD40L水平与所有变量均不相关。结论随年龄增加,1型糖尿病患者血清sCD40L水平有增高趋势,其并发血管病变的风险增加,因此,血清sCD40L水平的检测可作为1型糖尿病患者病情控制情况的衡量指标。Objective To investigate the significance of sCIMOL measurement in type 1 diabetic individuals without vascular complica- tions. Methods sCIMOL levels were determined by ELISA in diabetes mellitus and control groups. Results sCD40L levels in diabetes mellitus and control groupswere 2.39 ± 0.9ng/ml and 2.35 ± 1.1 ng/ml, respect - ively. There is no signif- icance. In the diabetic group, sCIMOL level correlated positively withage （r = 0.53, P 〈 0.01 ） , whereas in control group it didnot correlated with all variables. Conclusion sCD40L level and the risk of vascular complications tends to increase with age in type ldiabetic individuals. Therefore, sCD40L measurement might be used to evaluate the state of the ilIness.

关 键 词：SCD40L 1型糖尿病 血管并发症 

分 类 号：R587.1[医药卫生—内分泌]