心脏标志物检测在心脏病诊断中的意义  

The significance of detecting the heart markers for diagnosis and differential diagnosis of coronary atherosclerotic heart disease and pulmonary heart disease.

作　　者：郑辉[1] 欧二洪[1] 雷泽洪[1] 蔡萍金[1] 李健雄[1] 

机构地区：[1]江门市中心医院检验科,广东江门529000

出　　处：《中国热带医学》2005年第7期1495-1496,1594,共3页China Tropical Medicine

摘　　要：目的观察冠心病和肺心病病人血清心脏标志物浓度的变化,探讨其在上述疾病中诊断和鉴别诊断的意义。方法将收治的冠心病人195例分为A组,肺心病病人79例分为B组;又将195例冠心病病人中前壁心肌梗塞80例分为C组,39例下壁心肌梗塞分为D组,76例心绞痛分为E组。分别测定其血清肌钙蛋白I(TnI)、肌红蛋白(MYO)、肌酸激酶-同工酶(CK-MB)浓度。结果肺心病病人少部分MYO、CK-MB轻度升高外,其余在参考值范围;冠心病例3种标志物有不同程度升高。两组经非参数检验(P<0.01),有统计学意义。在冠心病病例中心肌梗塞组和心绞痛组的对比、心肌梗塞中前壁梗塞和下壁梗塞的对比,3种标志物升高程度不一,经配对非参数检验(P<0.01),皆有统计学意义。结论3种标志物检测对于冠心病的诊断、分型、危险分层和治疗及与肺心病的鉴别诊断有重要意义。Objective To investigate the significance of detecting serum heart markers in patients with coronary atheroselerotic heart disease and pulmonary heart disease. Methods There were totally 274 patients divided into Group A consisted of 195 patients with coronary heart disease and Group B consisted of 79 patients with pulmonary heart disease. While the 195 cases in Group A were again divided into Group C consisted of 80 patients with forward wall myocardial infarction, Group D consisted of 39 patients with below wall myocardial infarction and Group E consisted of 76 patients with angina. The concentration of TnI, MYO and CK - MB in serum all cases were measured. Results The concentration of MYO,CK-MB in the cases were normal in most of the cases with pulmonary heart disease and a little higher in a few cases. The concentration of Tnl, MYO and CK- Mb were increased at various extent in patients with coronary atherosclerotic heart disease, showing significant difference between Group A and B （ P 〈 0.01 ）. There were also significant differences in the increase of three markers between Group C, D and E after comparison （ P 〈 0.01 ）. Conclu- sion The detection of the three markers is of important significance in diagnosis and differentiating diagnosis of coronary atheroselerotie heart disease and pulmonary heart disease.

关 键 词：冠状动脉粥样硬化性心脏病 肺源性心脏病 生化标志物 

分 类 号：R541.4[医药卫生—心血管疾病]