治疗荨麻疹中药小复方筛选的思路与方法  

Ideas and Methods of Screening Small Compound Prescriptions of Chinese Medicine for Teatment of Urticaria

作　　者：张宏[1] 梁茂新[1] 李显华[1] 向绍杰[1] 杜佳林[1] 李坤[1] 包玉龙[1] 李为理 曲艳国 张文涛 李提宝 金凤环 

机构地区：[1]辽宁省中医药研究院,辽宁110034 [2]国家本溪中成药工程技术研究中心,本溪117004

出　　处：《世界科学技术-中医药现代化》2005年第4期54-60,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家中医药管理局资助课题(0203ZP20)中药小复方精选系统操作技术平台研究

摘　　要：本文以治疗荨麻疹中药小复方筛选为示范,介绍建立小复方筛选的技术平台。小复方的初筛,充分利用“《普济方》数据库管理系统”,结合现代研究成果,按照中医辨证论治和组方原则拟定;对不同处方及不同制备工艺进行药效学评价,以确定最佳组合和最佳制备工艺;再用均匀设计法对选定处方进行不同剂量配比的药效学评价,最终确定后续开发的精选小复方。Taking for demonstration the screening of small compound prescription of Chinese medicine for the treatment of urticaria, this article discusses how to establish the technical platform for the screening of small compound prescriptions. The first screening should be conducted by making full use of 'The Management System of《Puji Prescription》Database', in combination of modern research results and in accordance with the principles of diagnosis and treatment based on an overall analysis of the illness and the patients' condition as well as the composition of prescriptions of Chinese medicine; then the assessment of pharmacodynamics of various prescriptions and preparation techniques should be done in order to determine the best combination and preparation techniques; and finally the pharmacodynamic assessment of different dosage rates of prescriptions selected should be made by the method of uniform design so as to confirm the carefully -chosen small compound prescriptions to be developed.

关 键 词：中药 小复方 荨麻疹 技术平台 中药小复方 筛选 治疗 数据库管理系统 药效学评价 中医辨证论治 

分 类 号：R283.6[医药卫生—中药学] R275.982.4[医药卫生—中医学]