通络益肾汤对大鼠糖尿病性周围神经病变的治疗作用  

Therapeutic effects of Tongluoyishentang for diabetic peripheral neuropathy in rats

作　　者：赵容杰[1] 金相赞 金梅红[3] 梁在夏 赵正林[3] 

机构地区：[1]延边大学基础医学院药理学教研室,吉林延吉133000 [2]大邱韩医科大学 [3]延边大学基础医学院人体解剖学与组织胚胎学教研室,吉林延吉133000

出　　处：《延边大学医学学报》2005年第3期163-166,共4页Journal of Medical Science Yanbian University

摘　　要：[目的]观察通络益肾汤对糖尿病性周围神经病变的治疗效果.[方法]用链脲佐菌素制作大鼠糖尿病模型,12周后糖尿病治疗组大鼠每日灌胃给予通络益肾汤浓缩液78 mL/kg,4周后用电子显微镜观察大鼠坐骨神经的形态学变化.[结果]通络益肾汤对糖尿病周围神经病变大鼠坐骨神经的损伤有明显好转.[结论]通络益肾汤对糖尿病性周围神经病变有治疗作用.OBJECTIVE To study the therapeutic effects of Tongluoyishentang for diabetic peripheral neuropathy. METHODS The models of diabetes of rats were made by Streptozotocin （STZ）. 12 weeks after, rats in diabetic treatment group were given Tongluoyishentang 78.0 mL/kg for 4 weeks. The peripheral neuropathy of rats were observed under transmission electronic microscope. RESULTS The diabetic sciatic neuropathy of rats was significantly improved by Tongluoyishentang. CONCLUSION Tongluoyishentang has therapeutic effects for diabetic peripheral neuropathy.

关 键 词：糖尿病性神经病 糖尿病 实验性 植物 药用 大鼠 

分 类 号：R285.5[医药卫生—中药学]