血液中ATP含量随保存温度和保存时间变化的规律性研究及数学建模  

Trendency and Mathematical Model of Relationship of Blood ATP Content with Temperature and Time of Preservation

作　　者：任素萍 李成岳[2] 刘安 郑建弘[3] 钟仕增[2] 韩颖 

机构地区：[1]北京输血医学研究所,北京100850 [2]中央民族大学信息与计算科学学院,北京100081 [3]北京大学数学科学学院,北京100871

出　　处：《中国实验血液学杂志》2005年第5期896-900,共5页Journal of Experimental Hematology

基　　金：全军医学科研"十五"计划课题资助项目;编号01L040

摘　　要：为了研究血液中ATP含量随保存温度和保存时间变化的规律性并建立数学模型,以ATP含量作为血液质量的评判指标,对4-32℃区间不同保存温度条件下血液的质量变化进行了系统的研究,得出系列经验数据。结果表明:假设ATP的浓度y=f(d,t,s)是时间d、温度t和起始浓度s的连续函数,利用数理统计中的线性回归理论对模型加以拟合,得到了ATP浓度随保存温度和保存时间变化的一般数学物理方程,根据方程推算在4、6、8、10、12、14、16、18、20、22、24、26、28、30和32℃温度下,以CPDA1保存的全血分别可以有效保存35、35、29、22、18、18、13、8、7、6、6、5、4、4和3天。结论:本研究首次系统揭示了保存温度变化时血液质量变化的一般性规律,为准确判断变温血质量、指导临床合理用血提供科学参考。To investigate the relationship of blood ATP content with temperature and time of preservation and to establish its mathematical model, adenosine triphosphate （ATP） concentration was applied as the index of the quality of erythrocytes; systematical study on variation of blood preserved in a series of different temperatures from 4℃ to 32℃ was perfomed, and a series of experimental data were obtained. The results showed that when the ATP concentration y = f （d, t, s） in preserved blood was given as the continuous function of the time （d）, the temperature （t） and the initiate ATP concentration （s）, the model was fitted with the theory of linearity regression in symbolic statistics, and the general mathematical physical equation of the variation of preserved blood quality was deduced. According to the equation, the whole blood in CPDA-1 solution could be efficiently stored for 35, 35, 29, 22, 18, 18, 13, 8, 7, 6, 6, 5, 4, 4 and3 days in 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30 and 32℃, respectively. In conclusion, the general trendency of the variation of preserved blood quality according to the temperature and the time was systematically disclosed for the first time, which would be propitious to estimate the blood quality in various temperatures and to instruct clinical blood transfusion.

关 键 词：血液保存 ATP 线性回归 数学模型 

分 类 号：R331.1[医药卫生—人体生理学] R457.1[医药卫生—基础医学]