静脉药瘾者血源传播病毒感染情况的调查分析  

Analysis on the Infection Rates of Blood Transmission Virus in Intravenous Drug Users

作　　者：田昆仑[1] 王晶[1] 王一心[1] 郭利军[1] 

机构地区：[1]大理学院基础医学院,云南大理671000

出　　处：《大理学院学报（综合版）》2005年第5期46-48,共3页Journal of Dali University

基　　金：国家自然科学基金资助(30160083)

摘　　要：目的:调查静脉药瘾者主要血源传播病毒HBV、HCV、HGV、CMV和HSV的感染率。方法:采用酶联免疫吸附法、放射免疫法R、T-PCR和荧光定量PCR法,检测了406例静脉药瘾者血清,其中共用注射器者49.01%,同时设立102例正常健康体检者作为对照。结果:静脉药瘾者HBV、HCV、HGV、CMV和HSV的感染率分别是36.45%、69.7%、1.97%、2.71%和3.45%,其中总感染人数321人(79.06%)和重叠感染人数128人(31.53%),尤其有共用注射器者感染率及重叠感染率均高于未共用者,两者差异具有显著性意义(P<0.05)。对照组检测仅发现存在HBV感染(17.6%),其余病毒感染指标均为阴性。结论:静脉药瘾者血源传播病毒感染率明显增高,其中以HCV感染最为突出,并且共用注射器是导致感染扩大的危险要素。Objective： In order to assess CMV in Intravenous Drug Users （IVDUs） the infection condition of HBV,HCV,HGV,HSV and Methods： It is detected that anti-HBV,HCV,HGV, HSV,CMV markers by ELISA in 406 sera and 102 normal controls. While we detected HCV RNA by RT-PCR and Fluorescence Quantitative PCR methods. Results： The results showed that anti-HGV HSV and CMV positive is 1.97% ,2.71% and 3.45% respctively, total HBV infection rate is 36.45%, HBsAg carrier 5.91%, HBeAg positive 3.96% in IVDUs. HBV infection rate is 17.65%, HBsAg carrier 0.98%, HBeAg positive 1.96% in the controls. Others are negative. The infection rates and eoinfection rates are very prominent in the injector co-users of IVDUs （49.01%）. Conclusion： It indicates that IVDUs is high risk population of blood transmission virus infection, especially HCV infection.

关 键 词：静脉药瘾者 血源传播病毒 重叠感染 酶联免疫吸附法 

分 类 号：R511[医药卫生—内科学]