^(188)Re labeled MPEG-modified superparamagnetic nanogels: preparation and preliminary application in mice  

作　　者：SUN Han-Wen GONG Pei-Jun LIU Xiu-Qing MENG Fan-Zong WEI Xing-Guo HONG Jun XU Dong-Mei ZHANG Chun-Fu WANG Yong-Xian YAO Si-De 

机构地区：[1]Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800 [2]Dezhou University, Dezhou 253023

出　　处：《Nuclear Science and Techniques》2005年第5期278-282,共5页核技术（英文）

基　　金：Supported by Science and Technology Commission of Shanghai Municipality (No.0352nm120) and the Knowledge Innovation Pro-ject of Chinese Academy of Sciences (No.90120310).

摘　　要：Superparamagnetic poly(acrylamide) magnetic nanogels produced via photochemical method have been developed. After Hoffmann degradation of carbonyl, the nanogels with amino groups, or poly(acrylamide-vinyl amine) magnetic nanogels, were also obtained. And the magnetic nanogels were further modified by methoxy poly(ethylene glycol) (MPEG) for higher dispersibility and stability. The MPEG-modified magnetic nanogels were characterized by X-ray diffraction (XRD), photo correlation spectroscopy (PCS) and scanning electron microscopy (SEM), respectively. The MPEG-modified magnetic nanogels were labeled by 188Re radiopharmaceuticals and intra-venously injected into tails of mice in the presence and absence of a 0.5 T external magnetic field targeted on the bel-lies. The radioactivity distribution was monitored in vivo. In the absence of magnetic field, the radioactivity was mainly distributed in liver, spleen, kidney, stomach and lung. In the presence of the magnetic field, the radioactivity was mainly accumulated on the targeted point, verifying the magnetically targeted character.Superparamagnetic poly（acrylamide） magnetic nanogels produced via photochemical method have been developed. After Hoffmann degradation of carbonyl, the nanogels with amino groups, or poly（acrylamide-vinyl amine） magnetic nanogels, were also obtained. And the magnetic nanogels were further modified by methoxy poly（ethylene glycol） （MPEG） for higher dispersibility and stability. The MPEG-modified magnetic nanogels were characterized by X-ray diffraction （XRD）, photo correlation spectroscopy （PCS） and scanning electron microscopy （SEM）, respectively. The MPEG-modified magnetic nanogels were labeled by ^188 Re radiopharmaceuticals and intravenously injected into tails of mice in the presence and absence of a 0.5 T external magnetic field targeted on the bellies. The radioactivity distribution was monitored in vivo. In the absence of magnetic field, the radioactivity was mainly distributed in liver, spleen, kidney, stomach and lung. In the presence of the magnetic field, the radioactivity was mainly accumulated on the targeted point, verifying the magnetically targeted character.

关 键 词：铼 聚丙烯酰胺 光化学 碳酰基 氨基组团 

分 类 号：O635[理学—高分子化学] O644.1[理学—化学]