Comparative and optimized studies on radiosynthesis of O-(2-[^(18)F]fluoroethyl)-L-tyrosine  

作　　者：WANG Ming-Wei YIN Duan-Zhi WANG Yong-Xian CHENG Deng-Feng LI Gu-Cai ZHOU Wei 

机构地区：[1]Radiopharmaceutical Centre, Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800

出　　处：《Nuclear Science and Techniques》2005年第5期283-288,共6页核技术（英文）

基　　金：Supported by the Knowledge Innovation Project of Chinese Academy of Sciences (No.KJCX-SW-08) and the National Natural Sci-ence Foundation of China (No.30371634)

摘　　要：O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), one of radiolabelled amino acids, is a very promising brain tumor positron emission tomography (PET) imaging agent and holds clinical potential. This paper described out a comparative and optimized radiosynthesis of [18F]FET, concerning three aspects of its two-step preparation method, including reaction components, heating methods and reaction models. As a result, good radiochemical yield (about 45%, no-decay-corrected) and radiochemical purity (more than 95%) were achieved, and total synthesis time of [18F]FET was shortened within 20 min and radiation exposure time also decreased.O-（2-[^18F]fluoroethyl）_L-tyrosine （[^18F]FET）, one of radiolabelled amino acids, is a very promising brain tumor positron emission tomography （PET） imaging agent and holds clinical potential. This paper described out a comparative and optimized radiosynthesis of [^18F]FET, concerning three aspects of its two-step preparation method, including reaction components, heating methods and reaction models. As a result, good radiochemical yield （about 45%, no-decay-corrected） and radiochemical purity （more than 95%） were achieved, and total synthesis time of [^18F]FET was shortened within 20 min and radiation exposure time also decreased.

关 键 词：酪氨酸 放射合成 衍生物 氨基酸 

分 类 号：O629.71[理学—有机化学]