Interleukin-10 genotype protects end stage renal disease patients from microinflammation and arteriosclerosis  

作　　者：WU Hong-chi LING Hong NA Shi-ping XIE Ru-juan 

机构地区：[1]Department of Nephrology, First Affiliated Hospital, Harbin MedicalUniversity, Harbin 150001, China [2]Department of Immunity, Harbin Medical University, Harbin 150001, China

出　　处：《Chinese Medical Journal》2005年第18期1549-1551,共3页中华医学杂志（英文版）

基　　金：ThisstudywassupportedbyHeilongjiangProvincialStudyProject (No.GC01C145).

摘　　要：End stage renal disease （ ESRD ） and cardiovascular disease are induced by arteriosclerosis （AS）. The latest investigation shows that AS is a special inflammatory state. The constant inflammation,which has been defined as a micro inflammatory state is related to the decline of renal function and blood purification, but not the result of infections caused by external pathogenic microorganisms or internal opportunistic pathogenic microorganisms. We investigated the mechanism of interleukin-10 （IL-10） gene-1082 A/G protection effect to keep ESRD patients away from micro inflammation and AS.End stage renal disease （ ESRD ） and cardiovascular disease are induced by arteriosclerosis （AS）. The latest investigation shows that AS is a special inflammatory state. The constant inflammation,which has been defined as a micro inflammatory state is related to the decline of renal function and blood purification, but not the result of infections caused by external pathogenic microorganisms or internal opportunistic pathogenic microorganisms. We investigated the mechanism of interleukin-10 （IL-10） gene-1082 A/G protection effect to keep ESRD patients away from micro inflammation and AS.

关 键 词：end stage renal disease·interleukin-10·micro-inflammatory state·arteriosclerosis 

分 类 号：R692[医药卫生—泌尿科学]