重型乙型肝炎血清IL-1、IL-6和TNF-α水平的变化研究  

The change of the level of serum IL-1, IL-6 and TNF-α in patients with grave viral hepatitis B

作　　者：陈瑞烈[1] 王文锋[1] 周震[1] 刘敏[1] 

机构地区：[1]汕头市第二人民医院感染科,广东汕头515011

出　　处：《临床肝胆病杂志》2005年第5期273-274,共2页Journal of Clinical Hepatology

摘　　要：探讨血清IL-1、IL-6和TNF-α在重型乙型病毒性肝炎发病机理中的作用及临床意义。采用双抗体 夹心ELISA法检测36例重型乙型肝炎患者血清IL-1、IL-6和TNF-α水平。重型乙型肝炎患者血清IL-1、IL- 6、TNF-α水平均显著高于慢性乙型肝炎、急性乙型肝炎和正常人(P<0．01);其升高水平与血清ALT、TBil、PT呈显 著相关(P<0．05和P<0．01);重型乙型肝炎死亡者血清IL-1、IL-6和TNF-α水平显著高于存活者(P<0．01)。 重型乙型肝炎患者血清IL-1、IL-6、TNF-α水平与肝细胞坏死程度密切相关,检测血清中IL-1、IL-6、TNF-α对 判断病情危重程度和预后有重要意义。To investigate the role and clinical significance of serum interleukin- 1 （IL- 1 ）, interleukin- 6 （IL- 6）and tumor necrosis factor- α （TNF- α） in pathogenesis of grave viral hepatitis B. Using double - antibody sandwich ELISA to detect serum IL- 1, IL- 6 and TNF - α in 36 patients with grave viral hepatitis B. Serum IL - 1, IL - 6 and TNF - α in patients with grave viral hepatitis B is significantly higher than that in patients with chronic, acute hepatitis B and controls （ P 〈 0.01 ） ,the devated levels of IL- 1, IL - 6 and TNF - α were positively correlated with serum ALT,TBil and Pr （ P 〈 0.05 - 0.01 ）. Serum IL - 1, IL- 6 and TNF - α in patients who died of grave viral hepatitis B is significantly higher than that in survivor （ P 〈 0.01 ）. Serum IL - 1, IL- 6 and TNF - α in patients with grave viral hepatitis B has close relationship with the degree of necrosis of hepatocyte. Detect serum IL - 1, IL - 6 and TNF - α is helpful for judging the severity and prognosis of grave viral hepatihs B.

关 键 词：重型乙型病毒性肝炎 白细胞介素-1 白细胞介素-6 肿瘤坏死因子-α 

分 类 号：R512.62[医药卫生—内科学]