肾结石患者尿NAG和尿微量白蛋白动态检测及其意义  

Perioperative change of urinary N-acetyl-beta-D-glucosaminidase(NAG) and microalbumin(mAlB) in patients with renal calculi and its significance

作　　者：王露萍[1] 梁卓寅[1] 梁志雄[1] 黄锦坤[1] 李逊[1] 

机构地区：[1]广州医学院第一附属医院微创外科中心,广州510230

出　　处：《临床泌尿外科杂志》2005年第10期617-618,共2页Journal of Clinical Urology

摘　　要：目的:探讨肾结石患者手术前后尿酶变化及意义。方法:对167例肾结石患者在行微创经皮肾镜取石术(mPCNL)前1周、63例在mPCNL后1周、33例在mPCNL后1个月分别检测尿N-乙酰-β-D氨基葡萄糖苷酶(NAG)/Cr、mAlB/Cr。结果:与无肾结石对照组相比,mPCNL术前和术后1周的NAG/Cr和mAlB/Cr有统计学意义(P<0.01);mPCNL术后1周和术后1个月的NAG/Cr与术前无统计学意义,而mAlB/Cr有统计学意义(P<0.01)。mPCNL术后1个月与术后1周相比:NAG/Cr有统计学意义(P<0.05),而mAlB/Cr无统计学意义。结论:尿NAG、尿微量白蛋白可动态监测肾结石患者早期肾损害。Objective：To investigate the significance of change of urinary enzyme in patients with renal calculi before and after minimally invasive percutaneous nephrolithotomy （MPCNL）. Methods：The NAG/Cr and mAIB/ Cr value were analysed in 167 patients with renal calculi before MPCNL, one week after MPCNI. and a month af- ter MPCNL. Results：The level of NAG/Cr.mAIB/Cr in patients with renal calculi befor and after MPCNL were significantly higher than those in control group （ P〈0.01）. The level of NAG/Cr a week/a month after operation did not show significant difference compareing with that befor operation （ P〈0.05）. The level of mAIB/Cr was significantly elevated （ P〈0.01）. But the level of NAG/Cr ,mAIB/Cr a week after operation did not show significant changes comparing with that after operation a month （ P〈0.01）. Conclusions： The detection of urinary mAIB and NAG maybe a useful sensitive marker in monitoring early renal function damage in patients with renal calculi.

关 键 词：N-乙酰-Β-D氨基葡萄糖苷酶 微量白蛋白 肾结石 

分 类 号：R692.4[医药卫生—泌尿科学]