基因重组/尿卵泡刺激素对卵巢的反应及辅助生殖技术结局的对比性研究  

Comparison of recombinant and urinary FSH preparations to ovarian response and IVF/ICSI outcome

作　　者：徐仙[1] Rafael A.Cabrera Benjamin C.Wong 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004 [2]美国弗吉尼亚Jones生殖医学研究院,弗吉尼亚诺福克23507

出　　处：《宁夏医学杂志》2005年第10期651-654,共4页Ningxia Medical Journal

基　　金：国家留学基金资助项目(No.21864017)

摘　　要：目的评估基因重组和尿卵泡刺激素对不孕妇女卵巢的刺激反应和体外受精(IVF)或卵胞浆内单精子注射(ICSI)的妊娠结局。方法对1049例实施IVF或ICSI的不孕患者作回顾性分析,在2种促性腺激素释放激素激动剂(GnRHa)方案下,分别给予尿卵泡刺激素(uFSH)、高纯度尿卵泡刺激素(hpFSH)和基因重组卵泡刺激素(rFSH)促排卵,比较3组雌二醇(E2)峰值水平、FSH剂量、成熟卵母细胞数、受精率和妊娠率。结果在中度和高度卵巢反应者(GnRHa长方案)、hpFSH组和rFSH组出现较高的E2峰值和绒毛膜促性腺素的注射延迟,其中rFSH组的胚胎种植率和持续妊娠率最高;在低弱卵巢反应者(GnRHa短方案)、hpFSH组和rFSH组的E2峰值显著增高,其周期取消率也明显减低,但各组之间种植率或妊娠率无明显差异。结论本研究说明,在卵巢的反应性和IVF/IC-SI妊娠结局的层面上,基因重组卵泡刺激素较尿卵泡刺激素更显优越性。Objective To ccrapare ovarian response and IVF/ICSI outcome using recombinant and urinary FSH prepar4tions. Methods Retrospective, comparative analysis. 1049 patients undergoing WF and ICSI cycles. Patients receiving urinary FSH （uFSH）, highly purified urinary FSH （hpFSH） or recombinant FSH （rFSH） in combination with two different GnRH agonist （GnRHa） regimens （long and stop GnRHa protocols）. Main outcome measures： Peak estradiol （ E2 ） levels, number of gonadotropin ampoules administered, number of mature oocytes recovered, fertilization and pregnancy rates. Results In intermediate and high responder patients （long GnRHa protocol）, the use of hpFSH and rFSH resulted in higher peak E2 levels and in a delay in hCG administration; implantation and ongoing pregnancy rates were highest in patients receiving rFSH. In low responders （ stop GnRHa protocol ）, the use of hpFSH and rFSH resulted in a decreased cancellation rate and higher peak E2 levels; no differences in implantation or pregnancy rates were observed among groups. Conclusion This study demonstrated that a reccnabinant FSH appeared to be superior than urinary FSH preparations in regard to ovarian response and IVF/ICSI outcome.

关 键 词：基因重组卵泡刺激素 尿卵泡刺激素 卵巢反应性 妊娠 

分 类 号：R714.8[医药卫生—妇产科学]