对氧磷酯酶1与老年2型糖尿病患者血管并发症的关系研究  

A Study on the Relation between Paraoxonase 1 and Type 2 Diabetes Mellitus with Vascular Complications in the Elderly

作　　者：孙亚威[1] 尚可[2] 郭建政[3] 

机构地区：[1]河北省邯郸市第一医院内分泌科,056002 [2]河北工程学院医学院 [3]邯郸市铁路医院内科

出　　处：《中国全科医学》2005年第20期1669-1670,共2页Chinese General Practice

摘　　要：目的探讨血清对氧磷酯酶1(PON1)活性与老年2型糖尿病(DM)及并发症的关系。方法以对氧磷为底物测定老年2型糖尿病各组患者及健康老年人血清PON1活性。结果2型糖尿病组患者与健康对照组老年人血清PON1活性间差别有显著性意义(P<0.01);老年2型糖尿病合并微血管病变组患者与老年2型糖尿病组患者血清PON1活性间差别有显著性意义(P<0.01)。结论PON1活性在老年2型糖尿病及并发血管病变患者中均显著降低,提示PON1活性的降低参与了糖尿病血管并发症的发生。Objective To study the relation between serum paraoxonase 1 （ PON1 ） activity and type 2 diabetes mellitus with vascular complications in the elderly, Methods Serum PON1 activity was measured by using paraoxonase as the substrate among the elderly with type 2 and the normal healthy people. Results PON1 activity was much lower in the elderly groups with type 2 diabetes mellitus than that of the controls [ （ 125. 14± 34. 22） IU/L vs （ 183.52 ±49.45 ） IU/L, P 〈0. 01 ] and PON1 activity was much lower in type 2 diabetic patients combined with macroangiopathy and microangiopathy [ （94.49 ± 28. 87 ） IU/L and （93.26±26. 81 ） IU/L3 than that of the simple type 2 diabetic patients （ P 〈0. 01 ）. Serum PON1 activity was much lower in the elderly patients with type 2 diabetes mellitus and diabetic vascular complications. Conclusion The lower serunl PON1 activity may play a role in elderly patients with type 2 diabetes mellitus and diabetic vascular complications.

关 键 词：对氧磷酯酶1 糖尿病 非胰岛素依赖性 糖尿病血管病变 

分 类 号：R587.2[医药卫生—内分泌]