四氢巴马汀对在体犬跨室壁复极离散度的影响  

Effects of L-tetrahyd ropalmatine on the Transmural Dispersion of Repolarization of Canine in Vivo.

作　　者：来春林[1] 刘福元[1] 曾秋棠[1] 毛奕[1] 祈爱萍 曹林生[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院心血管病研究所,湖北武汉430060 [2]湖北省襄樊市第一人民医院心血管内科

出　　处：《中国心脏起搏与心电生理杂志》2005年第5期382-384,共3页Chinese Journal of Cardiac Pacing and Electrophysiology

摘　　要：从跨室壁复极离散度(TDR)的角度研究左旋四氢巴马汀(L-THP)的电生理作用。采用自制电极同步记录在体犬左室三层心肌细胞的单向动作电位(MAP),观察静脉注射L-THP前后动作电位时程(APD)、振幅(APA)、TDR及各层心肌有效不应期(ERP)的变化。结果:应用L-THP后三层心肌的动作电位复极90%的时程均延长(内、中、外层心肌分别为189.67±23.29msvs182.83±23.70ms、194.67±24.12msvs192.17±24.49ms和185.08±24.53msvs173.42±22.06ms,P均<0.01),内、外层心肌ERP显著增加(分别为164.54±20.53msvs159.08±20.08ms、161.60±21.28msvs150.99±18.93ms,P<0.01)、TDR降低(9.58±2.94msvs18.75±3.77ms,P<0.01),对APA无明显影响。结论:L-THP降低心室肌的TDR,延长心室内、外膜心肌细胞的ERP。To investigate the electrophysiological effects of L-tetrahydropalmatine （ L- THP） on transmural dispersion of repolarization （TDR） , monophasic action potential （MAP） from the sub-endocardium （sub-Endo） , mid-myocardial （Mid） and sub-epicardium （sub-Epi） of canine left ventricular anterior wall was recorded with a self-made electrodes simultaneously. The diversification of TDR, the action potential duration （ APD）, the amplitude of action potential （APA） and the effective refractory period （ERP） were compared before and after the intravenous injection of L-THP. Results ： After the intravenous injection of L-THP, APD90 of sub-Endo, Mid and sub-Epi myocardium were significantly increased （189.67 ±23.29 ms vs 182.83 ±23.70 ms, 194.67 ±24.12 ms vs 192.17 ±24.49 ms and 185.08 ± 24.53 ms vs 173.42 ± 22.06 ms respectively, all P 〈 0. 01 ）. ERP in the sub-Endo and sub-Epi was significantly increased（ 164.54 ± 20.53 ms vs 159.08 ± 20.08 ms, 161.60 ± 21.28 ms vs 150.99 ± 18.93 ms respectively ,P 〈 0.01 ）, but TDR decreased （9.58 ± 2.94 ms vs 18.75 ± 3.77ms,P 〈 0.01 ） significantly, and no significant impact on the APA of three myocardium layer could be detected. Conclusions ： TDR of ventricular myocardium can be decreased and ERP of both sub-Endo and sub-Epi myocardium can be prolonged by L-THP. [ Chinese Journal of Cardiac Pacing and Electrophysiology, 2005,19（5） ：382 - 384 ]

关 键 词：电生理学 四氢巴马汀 跨室壁复极离散度 单向动作电位 心律失常 室性 

分 类 号：R331.38[医药卫生—人体生理学] R972.2[医药卫生—基础医学]